Comparative Transcriptome Profiling Provides New Insights Into Mechanisms of Androgenetic Alopecia Progression

May 2016 in “ British Journal of Dermatology ”

Elaine G.Y. Chew, B.S.‐Y. Ho, S. Ramasamy, Todd E. Dawson, Chandana Tennakoon, Xia-Ji Liu, W.M.S. Leong, S.Y.S. Yang, S.Y.D. Lim, H. Jaffar, Axel M. Hillmer, Mei Bigliardi-Qi, Paul L. Bigliardi

androgenetic alopecia hair follicles lipid synthesis electron transport miniaturization of hair follicles AGA

TLDR AGA progression involves increased lipid synthesis, electron transport, and hair follicle miniaturization.

This study analyzed the transcriptome of hair follicles in patients with androgenetic alopecia (AGA) and compared them to controls. The results showed that lipid synthesis and electron transport related genes were up-regulated in AGA patients compared to controls. Additionally, miniaturization of hair follicles was observed in AGA patients. The study provides new insights into the mechanisms of AGA progression.

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