Comparative Transcriptome Profiling Provides New Insights Into Mechanisms of Androgenetic Alopecia Progression

May 2016 in “ British Journal of Dermatology ”

Elaine G.Y. Chew, B.S.‐Y. Ho, S. Ramasamy, Todd E. Dawson, Chandana Tennakoon, Xia-Ji Liu, W.M.S. Leong, S.Y.S. Yang, S.Y.D. Lim, H. Jaffar, Axel M. Hillmer, Mei Bigliardi-Qi, Paul L. Bigliardi

androgenetic alopecia hair follicles lipid synthesis electron transport miniaturization of hair follicles AGA

Studysummary This article reviews androgenetic alopecia and its underlying mechanisms, highlighting genetic and androgen factors in its onset, and does not report new research results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This study analyzed the transcriptome of hair follicles in patients with androgenetic alopecia (AGA) and compared them to controls. The results showed that lipid synthesis and electron transport related genes were up-regulated in AGA patients compared to controls. Additionally, miniaturization of hair follicles was observed in AGA patients. The study provides new insights into the mechanisms of AGA progression.

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