Comparative Proteomic Analysis of Male and Female Androgenetic Alopecia: Elucidating Gender-Specific Molecular Patterns

    Sasin Charoensuksira, Jitlada Meephansan, Raksanawan Vanichvongvan, Poorichaya Somparn, Pattarin Tangtanatakul, Jongkonnee Wongpiyabovorn, Poonkiat Suchonwanit
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    TLDR Male and female pattern hair loss have different molecular pathways, suggesting unique treatment targets for each sex.
    This study conducted a comparative proteomic analysis to investigate the molecular mechanisms of androgenetic alopecia (AGA) in males and females. By analyzing scalp samples from both male and female AGA patients and their normal controls, researchers identified 68 differentially expressed proteins in male AGA and 84 in female AGA. The study revealed distinct sex-specific molecular pathways involved in pattern hair loss, with notable differences in cytoskeleton organization, stress response, and metabolic pathways between the sexes. These findings suggest potential biomarkers and therapeutic targets, offering new insights into the sex-specific pathogenesis of pattern hair loss.
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