Hair Growth Promoting Effects of 650 nm Red Light Stimulation on Human Hair Follicles and Study of Its Mechanisms via RNA Sequencing Transcriptome Analysis

    January 2021 in “ Annals of Dermatology ”
    Kai Yang, Yulong Tang, Yanyun Ma … Wenyu Wu
    Studysummary This study found that 650-nm red light treatment promoted hair follicle proliferation and delayed the transition from anagen to catagen in ex vivo hair follicles from androgenetic alopecia patients, with RNA-seq analysis suggesting involvement of biological processes like metabolism and leukocyte migration.
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    Research cited in this study 24

    1. Global Expression Profile and Genome Methylation Signatures in Male Patients with Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 2019
    2. Topical Ketoconazole for the Treatment of Androgenetic Alopecia: A Systematic Review Dermatologic Therapy · 2019
    3. Androgenetic Alopecia: Combing the Hair Follicle Signaling Pathways for New Therapeutic Targets and More Effective Treatment Options Expert Opinion on Therapeutic Targets · 2019
    4. Deciphering the Molecular Morphology of the Human Hair Cycle: Wnt Signalling During the Telogen–Anagen Transformation British Journal of Dermatology · 2019
    5. Quantitative Proteomic Analysis of Dermal Papilla from Male Androgenetic Alopecia Comparing Before and After Treatment with Low-Level Laser Therapy Lasers in Surgery and Medicine · 2019
    6. Evaluating Hair Growth Promoting Effects of Candidate Substances: A Review of Research Methods Journal of Dermatological Science · 2019
    7. Comparative Effectiveness of Low-Level Laser Therapy for Adult Androgenic Alopecia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Lasers in Medical Science · 2019
    8. Low-Level Laser Therapy for the Treatment of Androgenetic Alopecia in Thai Men and Women: A 24-Week, Randomized, Double-Blind, Sham Device-Controlled Trial Lasers in Medical Science · 2018
    9. Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms International Journal of Molecular Sciences · 2018
    10. Activation of Wnt/β-Catenin Signaling Is Involved in Hair Growth-Promoting Effect of 655-nm Red Light and LED in In Vitro Culture Model Lasers in Medical Science · 2018
    11. Wnt/β-Catenin and ERK Pathway Activation: A Possible Mechanism of Photobiomodulation Therapy with Light-Emitting Diodes That Regulate the Proliferation of Human Outer Root Sheath Cells Lasers in Surgery and Medicine · 2017
    12. Androgens and Androgen Receptor Action in Skin and Hair Follicles Molecular and Cellular Endocrinology · 2017
    13. A New Path in Defining Light Parameters for Hair Growth: Discovery and Modulation of Photoreceptors in Human Hair Follicle Lasers in surgery and medicine · 2017
    14. Infundibular Protein and RNA Microarray Analyses from Affected and Clinically Non-Affected Scalp in Male Androgenetic Alopecia Patients Experimental Dermatology · 2017
    15. A Critical Assessment of the Evidence for Low-Level Laser Therapy in the Treatment of Hair Loss Dermatologic Surgery · 2016
    16. Hair Restoration in Androgenetic Alopecia: Looking Beyond Minoxidil, Finasteride, and Hair Transplantation Journal of cosmetology & trichology · 2016
    17. Visible Red Light Enhances Physiological Anagen Entry In Vivo And Has Direct And Indirect Stimulatory Effects In Vitro Lasers in surgery and medicine · 2014
    18. Low-Level Laser Therapy for Treatment of Hair Loss Lasers in Surgery and Medicine · 2013
    19. Alopecia Areata: An Update Indian Journal of Dermatology, Venereology and Leprology · 2013
    20. The Nuts and Bolts of Low-Level Laser Therapy Annals of Biomedical Engineering · 2011
    21. Effects of the Lexington LaserComb on Hair Regrowth in the C3H/HeJ Mouse Model of Alopecia Areata Lasers in Medical Science · 2011
    22. Human Hair Growth Ex Vivo Is Correlated With In Vivo Hair Growth: Selective Categorization of Hair Follicles for More Reliable Hair Follicle Organ Culture Archives of Dermatological Research · 2005
    23. Prevalence of Male and Female Pattern Hair Loss in Maryborough Journal of Investigative Dermatology Symposium Proceedings · 2005
    24. Androgenetic Alopecia in Men Aged 40-69 Years: Prevalence and Risk Factors British Journal of Dermatology · 2003

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