Global Expression Profile and Genome Methylation Signatures in Male Patients with Androgenetic Alopecia

    January 2020 in “ Journal of The European Academy of Dermatology and Venereology ”
    Lizeth Martínez-Jacobo, Claudia I Ancer-Arellano, Cesar Daniel Villarreal-Villarreal, Rocio Ortiz-Lopez, M Montufar-Martinez, Victor Trevino, SK Santuario-Facio, R Sanchez-Cornejo, Adriana Sánchez-García, Carlos E. Medina-De la Garza, Jesús Ancer-Rodríguez, Rodney Sinclair, Jorge Ocampo-Candiani, Augusto Rojas-Martinez
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    TLDR Differences in gene expression and methylation patterns found in AGA patients suggest potential targets for future treatments.
    The study analyzed the global expression profile and genome methylation signatures in male patients with androgenetic alopecia (AGA). The researchers found significant differences in gene expression and methylation patterns between AGA patients and control subjects, identifying several genes that were differentially expressed in AGA patients, including KIAA1609, ZNF83, and GP1BB. The study suggests that these genes may play a role in the development of AGA and could be potential targets for future treatments. However, the study was limited by its small sample size of 10 patients and 10 controls.
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