Evaluation of Susceptibility Genes and Loci Associated with Male Androgenetic Alopecia for Female-Pattern Hair Loss in a Chinese Han Population and a Brief Literature Review

August 2021 in “ Medical Science Monitor ”

Bo Liang, Yantao Ding, Yi Zhou, Chunjun Yang, Zhi-Xiang Cheng

androgenetic alopecia male androgenetic alopecia MAGA female-pattern hair loss FPHL genetic loci genome-wide approaches male-pattern baldness female-pattern baldness

TLDR Male and female hair loss have different genetic causes.

This study investigated whether genetic loci associated with male androgenetic alopecia (MAGA) also conferred susceptibility to female-pattern hair loss (FPHL) in a Chinese Han population. It included 82 FPHL patients and 381 healthy controls, analyzing 22 previously reported MAGA-associated sites. The results showed no significant association between these loci and FPHL, suggesting that FPHL and MAGA were etiologically distinct. This finding aligned with previous studies in European populations. The study concluded that future research should employ systematic genome-wide approaches to better understand the genetic basis of FPHL.

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Research cited in this study

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