Improvement of Androgenic Alopecia by Extracellular Vesicles Secreted from Hyaluronic Acid-Stimulated Induced Mesenchymal Stem Cells

    September 2024 in “ Stem Cell Research & Therapy
    Hyun Geun Oh, Minyoung Jung, Seon-Yeong Jeong, Jimin Kim, Sang‐Deok Han, Hongduk Kim, Seulki Lee, Yejin Lee, Haedeun You, Somi Park, Kun-Hyung Kim, Tae Min Kim, Soo Jeong Kim
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    TLDR HA-stimulated stem cell vesicles improved hair growth in male mice with androgenetic alopecia.
    The study demonstrates that extracellular vesicles (EVs) derived from hyaluronic acid-stimulated induced mesenchymal stem cells (HA–iMSC–EVs) significantly improve androgenetic alopecia (AGA) in male mice. These EVs enhance hair growth by blocking androgen receptor (AR) expression and reactivating the Wnt/β-catenin signaling pathway, showing effects comparable to finasteride, a common AGA treatment. The research involved 25 mice and suggests that HA–iMSC–EVs could be a promising alternative to conventional AGA therapies, offering improved outcomes without the side effects associated with current treatments.
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