Differences in Reproductive Toxicology Between Alopecia Drugs: An Analysis on Adverse Events Among Female and Male Cases

    October 2016 in “ Oncotarget ”
    Min Wu, Qiang Yu, Qingfeng Li
    Studysummary This study found that finasteride was associated with more reproductive adverse effects, including sexual dysfunction in men and fetal harm in women, compared to minoxidil in reported alopecia cases.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on oncotarget.com →
    Discuss this study in the Community →

    Research cited in this study 26

    1. Effects of a Novel Finasteride 0.25% Topical Solution on Scalp and Serum Dihydrotestosterone in Healthy Men with Androgenetic Alopecia International Journal of Clinical Pharmacology and Therapeutics · 2015
    2. Combined Treatment with Oral Finasteride and Topical Minoxidil in Male Androgenetic Alopecia: A Randomized and Comparative Study in Chinese Patients Dermatologic Therapy · 2015
    3. Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia: A Meta-Analysis PubMed · 2015
    4. Topical Minoxidil Fortified with Finasteride: Maintenance of Hair Density After Replacing Oral Finasteride Indian Dermatology Online Journal · 2015
    5. Finasteride 5 mg/Day Treatment of Patterned Hair Loss in Normo-Androgenetic Postmenopausal Women International Journal of Trichology · 2013
    6. Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects The Journal of Clinical Psychiatry · 2012
    7. Efficacy of Finasteride 1.25 mg on Female Pattern Hair Loss: Pilot Study Annals of Dermatology · 2012
    8. Efficacy and Tolerability of 5% Minoxidil Solution (Carexidil) in Male and Female Androgenetic Alopecia: A 6-Month Open Multicentric Study PubMed · 2011
    9. Central Chorioretinopathy Associated with Topical Use of Minoxidil 2% for Treatment of Baldness Cutaneous and Ocular Toxicology · 2011
    10. Efficacy and Safety of Finasteride Therapy for Androgenetic Alopecia Archives of Dermatology · 2010
    11. A Mouse Model of Androgenetic Alopecia Endocrinology · 2010
    12. Androgenetic Alopecia in Males: A Histopathological and Ultrastructural Study Journal of Cosmetic Dermatology · 2009
    13. Hair Loss in Women: Comprehensive Overview and Treatment Options Seminars in Cutaneous Medicine and Surgery · 2009
    14. Androgenetic Alopecia: Stress of Discovery Psychological Reports · 2006
    15. Evaluation and Treatment of Male and Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2004
    16. A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2004
    17. An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia Dermatology · 2004
    18. Comparative Efficacy of Various Treatment Regimens for Androgenetic Alopecia in Men Journal of Dermatology · 2002
    19. Allergic Contact Dermatitis to Topical Minoxidil Solution: Etiology and Treatment Journal of The American Academy of Dermatology · 2002
    20. Lack of Efficacy of Finasteride in Postmenopausal Women with Androgenetic Alopecia Journal of The American Academy of Dermatology · 2000
    21. The Effects of Finasteride on Scalp Skin and Serum Androgen Levels in Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1999
    22. Clinical Dose Ranging Studies with Finasteride, a Type 2 5α-Reductase Inhibitor, in Men with Male Pattern Hair Loss Journal of The American Academy of Dermatology · 1999
    23. Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells British Journal of Dermatology · 1998
    24. Potassium Channel Conductance: A Mechanism Affecting Hair Growth Both In Vitro and In Vivo Journal of Investigative Dermatology · 1992
    25. The Effect of Topical Minoxidil on Hair Follicular Cycles of Rats Journal of Dermatology · 1990
    26. Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography Journal of Investigative Dermatology · 1984

    Related research 10

    1. What's New in Therapy for Male Androgenetic Alopecia? American Journal of Clinical Dermatology · 2022
    2. Pharmacological Therapeutics in Androgenetic Alopecia Journal of The Korean Medical Association · 2020
    3. A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 2018
    4. Differences in Reproductive Toxicology Between Alopecia Drugs: An Analysis on Adverse Events Among Female and Male Cases Oncotarget · 2016
    5. Finasteride in the Treatment of Female Androgenic Alopecia PharmaTutor · 2014
    6. Daily Finasteride Boosts Hair Growth in Men Dermatology Times E-News · 2012
    7. Finasteride in the Treatment of Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2004
    8. Finasteride in the Treatment of Alopecia Expert Opinion on Pharmacotherapy · 2004
    9. Advances in the Treatment of Male Androgenetic Alopecia: A Brief Review of Finasteride Studies PubMed · 2001
    10. 5α-Reductase Inhibitors in the Treatment of Androgenetic Alopecia International Journal of Cosmetic Surgery and Aesthetic Dermatology · 2001