Human Placental Extract Exerts Hair Growth-Promoting Effects Through the GSK-3β Signaling Pathway in Human Dermal Papilla Cells

    August 2015 in “ International Journal of Molecular Medicine ”
    Tae‐Rin Kwon, Chang Taek Oh, Eui Yul Choi, Hye Min Park, Hyun Jung Han, Hyi-Jeong Ji, Beom Joon Kim
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    TLDR Human placental extract may help hair growth by affecting certain cell signals and could be more effective with minoxidil.
    The document presents a study that explored the hair growth-promoting effects of human placental extract (HPE) on human dermal papilla cells (hDPCs) and its potential use in treating hair loss. The study found that HPE promotes hair growth by inducing β-catenin expression through the inhibition of glycogen synthase kinase-3β (GSK-3β). HPE increased the viability and alkaline phosphatase (ALP) expression of hDPCs in a concentration-dependent manner. When combined with minoxidil (MXD), HPE was more effective in inhibiting GSK-3β and promoting hair elongation in rat vibrissa follicles. Additionally, HPE decreased the expression of TGF-β2, which is known to prevent apoptosis in the hair bulb region. The study suggests that HPE, especially when used with MXD, could be a novel therapeutic strategy for clinical hair loss treatment by activating the β-catenin/GSK-3β signaling pathway. The results are based on at least 3 independent experiments, but the exact number of hDPCs used is not specified, and further research is needed to confirm these findings.
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