Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition from Telogen to Anagen Phase

    March 2022 in “ Frontiers in Cell and Developmental Biology ”
    Hyo-Suk Kim, Yeongji Jang, Eun Kyung Kim … Yoosoo Yang
    Studysummary This study found that exosomes derived from bovine colostrum promoted hair growth in mice by activating the Wnt/β-catenin pathway, with effects similar to minoxidil but without adverse effects.
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    Research cited in this study 18

    1. Functional Hair Follicle Regeneration: An Updated Review Signal Transduction and Targeted Therapy · 2021
    2. Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling Science Advances · 2020
    3. Vanillic Acid Stimulates Anagen Signaling via the PI3K/Akt/β-Catenin Pathway in Dermal Papilla Cells Biomolecules & Therapeutics · 2020
    4. Role of Lactoferrin in Chronic Telogen Effluvium QJM: An International Journal of Medicine · 2020
    5. Beta-Catenin-Mediated Hair Growth Induction Effect of 3,4,5-Tri-O-Caffeoylquinic Acid Aging · 2019
    6. Lactoferrin Promotes Hair Growth in Mice and Increases Dermal Papilla Cell Proliferation Through Erk/Akt and Wnt Signaling Pathways Archives of Dermatological Research · 2019
    7. Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres Experimental Dermatology · 2019
    8. A Novel and Safe Small Molecule Enhances Hair Follicle Regeneration by Facilitating Metabolic Reprogramming Experimental and Molecular Medicine · 2018
    9. Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice Scientific Reports · 2017
    10. Differences in Reproductive Toxicology Between Alopecia Drugs: An Analysis on Adverse Events Among Female and Male Cases Oncotarget · 2016
    11. Androgenetic Alopecia: An Update Of Treatment Options Drugs · 2016
    12. Roles of GasderminA3 in Catagen–Telogen Transition During Hair Cycling Journal of Investigative Dermatology · 2015
    13. Exposure to Gamma-Rays at the Telogen Phase of the Hair Cycle Inhibits Hair Follicle Regeneration at the Anagen Phase in Mice International Journal of Radiation Biology · 2013
    14. Cause of Androgenic Alopecia Plastic and reconstructive surgery. Global open · 2013
    15. Hair Growth-Promoting Activity of Hot Water Extract of Thuja Orientalis BMC Complementary and Alternative Medicine · 2013
    16. Hair Growth-Promoting Effect of Aconiti Ciliare Tuber Extract Mediated by the Activation of Wnt/β-Catenin Signaling Life Sciences · 2012
    17. Male Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2010
    18. Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2003

    Related research 8

    1. Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition from Telogen to Anagen Phase Frontiers in Cell and Developmental Biology · 2022
    2. Exosomal miRNA-181a-5p from Hair Follicle Dermal Papilla Cells Promotes Hair Follicle Growth and Development via the Wnt/β-Catenin Signaling Pathway International journal of biological macromolecules · 2022
    3. KY19382, A Novel Activator of Wnt/β-Catenin Signalling, Promotes Hair Regrowth and Hair Follicle Neogenesis British Journal of Pharmacology · 2021
    4. Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling Science Advances · 2020
    5. KY19382, A Novel Activator of Wnt/β-Catenin Signaling, Promotes Hair Regrowth and Hair Follicle Neogenesis 2020
    6. The Role of Extracellular Vesicles in Cutaneous Remodeling and Hair Follicle Dynamics International Journal of Molecular Sciences · 2019
    7. Platelet-Derived Growth Factor Signaling Modulates Adult Hair Follicle Dermal Stem Cell Maintenance and Self-Renewal npj Regenerative Medicine · 2017
    8. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010