Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition from Telogen to Anagen Phase

March 2022 in “ Frontiers in Cell and Developmental Biology ”

Hyo-Suk Kim, Yeongji Jang, Eun Kyung Kim, Hochung Jang, Ha-Eun Cho, Geonhee Han, Hyun Kyu Song, Sun Yeou Kim, Yoosoo Yang

colostrum-derived exosomes Milk-exo hair regeneration telogen phase anagen phase dermal papilla cells DHT dihydrotestosterone β-catenin hair follicles hair growth hair loss

Studysummary This study found that exosomes derived from bovine colostrum promoted hair growth in mice by activating the Wnt/β-catenin pathway, with effects similar to minoxidil but without adverse effects.

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The study investigates the potential of colostrum-derived exosomes (Milk-exo) for promoting hair regeneration by transitioning hair follicles from the telogen to anagen phase. Milk-exo was found to induce the proliferation of dermal papilla (DP) cells, crucial for hair growth, and counteract the inhibitory effects of dihydrotestosterone (DHT) on these cells. In vivo experiments on C57BL/6 mice showed that Milk-exo significantly improved hair growth, evidenced by increased β-catenin expression in hair follicles. The findings suggest that Milk-exo could offer a promising, less-invasive treatment for hair loss with minimal adverse effects.

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