Adipose Transcriptome in the Scalp of Androgenetic Alopecia

    September 2023 in “ Frontiers in Medicine ”
    Criselda Jean G. Cruz, Yi‐Kai Hong, Wilson Jr F. Aala … Chao‐Chun Yang
    Studysummary This study observed that in the bald scalps of male patients with androgenetic alopecia, there was a significant downregulation of the PPAR signaling pathway, suggesting reduced adipogenesis potentially influencing hair cycling processes.
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    Research cited in this study 12

    1. Discovery of a Transdermally Deliverable Pentapeptide for Activating AdipoR1 to Promote Hair Growth EMBO Molecular Medicine · 2021
    2. Dermal Adipose Tissue Secretes HGF to Promote Human Hair Growth and Pigmentation Journal of Investigative Dermatology · 2021
    3. Quantitative Analysis of the Anatomical Changes in the Scalp and Hair Follicles in Androgenetic Alopecia Using Magnetic Resonance Imaging Skin Research and Technology · 2020
    4. PPAR-γ Signaling as a Key Mediator of Human Hair Follicle Physiology and Pathology Experimental Dermatology · 2019
    5. Androgens Modify Wnt Agonists/Antagonists Expression Balance in Dermal Papilla Cells Preventing Hair Follicle Stem Cell Differentiation in Androgenetic Alopecia Molecular and Cellular Endocrinology · 2016
    6. Hair Follicles’ Transit-Amplifying Cells Govern Concurrent Dermal Adipocyte Production Through Sonic Hedgehog Genes & Development · 2016
    7. Leptin of Dermal Adipose Tissue Is Differentially Expressed During the Hair Cycle and Contributes to Adipocyte-Mediated Growth Inhibition of Anagen-Phase Vibrissa Hair Experimental Dermatology · 2014
    8. Epidermal Wnt/β-Catenin Signaling Regulates Adipocyte Differentiation via Secretion of Adipogenic Factors Proceedings of the National Academy of Sciences of the United States of America · 2014
    9. Advanced Inhibition of Undesired Human Hair Growth by PPARγ Modulation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2013
    10. Hair Growth-Promoting Effects of Adiponectin In Vitro Journal of Investigative Dermatology · 2012
    11. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    12. Expression of Peroxisome Proliferator Activated Receptors (PPARs) in Human Hair Follicles and PPARα Involvement in Hair Growth Acta dermato-venereologica · 2000

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    1. Adipose Transcriptome in the Scalp of Androgenetic Alopecia Frontiers in Medicine · 2023