Discovery of a Transdermally Deliverable Pentapeptide for Activating AdipoR1 to Promote Hair Growth

    September 2021 in “ EMBO Molecular Medicine
    Jungyoon Ohn, Kyung Wook Been, Jin Yong Kim, Sang Hyun Kim, Tae‐Yong Park, Hye Jin Yoon, Jeong Seok Ji, Miki Okada-Iwabu, Masato Iwabu, Toshimasa Yamauchi, Yeon Kyung Kim, Chaok Seok, Ohsang Kwon, Kyu Han Kim, Hyung Ho Lee, Jin Ho Chung
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    TLDR A new small peptide may help hair growth by activating a specific receptor and should be tested in humans.
    The document discusses a study that identified a small, transdermally deliverable 5-mer peptide (GLYYF; P5) that activates adiponectin receptor 1 (AdipoR1) and promotes hair growth. The peptide was found to accelerate hair growth ex vivo and induce the anagen hair cycle in mice in vivo. The study involved 38 human hair follicles from three independent donors for ex vivo tests and 16 mice per group for in vivo tests. The researchers concluded that P5 is a promising drug candidate for alleviating alopecia and suggested that human clinical trials are necessary to further explore its potential.
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