Discovery of a Transdermally Deliverable Pentapeptide for Activating AdipoR1 to Promote Hair Growth

September 2021 in “ EMBO Molecular Medicine ”

Jungyoon Ohn, Kyung Wook Been, Jin Yong Kim, Sang Hyun Kim, Tae‐Yong Park, Hye Jin Yoon, Jeong Seok Ji, Miki Okada-Iwabu, Masato Iwabu, Toshimasa Yamauchi, Yeon Kyung Kim, Chaok Seok, Ohsang Kwon, Kyu Han Kim, Hyung Ho Lee, Jin Ho Chung

pentapeptide GLYYF P5 adiponectin receptor 1 AdipoR1 hair growth anagen hair cycle alopecia 5-mer peptide hair cycle hair loss

TLDR A new small peptide may help hair growth by activating a specific receptor and should be tested in humans.

The document discusses a study that identified a small, transdermally deliverable 5-mer peptide (GLYYF; P5) that activates adiponectin receptor 1 (AdipoR1) and promotes hair growth. The peptide was found to accelerate hair growth ex vivo and induce the anagen hair cycle in mice in vivo. The study involved 38 human hair follicles from three independent donors for ex vivo tests and 16 mice per group for in vivo tests. The researchers concluded that P5 is a promising drug candidate for alleviating alopecia and suggested that human clinical trials are necessary to further explore its potential.

View this study on embopress.org →

Discuss this study in the Community →

Cited in this study

16 / 16 results

research Discovery of a Transdermally Deliverable Pentapeptide for Activating AdipoR1 to Promote Hair Growth

8 citations , September 2021 in “EMBO Molecular Medicine”

A new small peptide may help hair growth by activating a specific receptor and should be tested in humans.

research Stimulation of Hair Growth by Small Molecules That Activate Autophagy

88 citations , June 2019 in “Cell reports”

Certain small molecules can promote hair growth by activating a cellular cleanup process called autophagy.

research Evaluating Hair Growth Promoting Effects of Candidate Substances: A Review of Research Methods

28 citations , March 2019 in “Journal of Dermatological Science”

The document concludes that while lab results for hair growth promotion are promising, human trials are needed and better testing methods should be developed.

research Topically Applied Nicotinamide Inhibits Human Hair Follicle Growth Ex Vivo

13 citations , June 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Nicotinamide applied to the scalp can slow down hair growth.

research The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis

178 citations , July 2017 in “Journal of The American Academy of Dermatology”

Minoxidil, finasteride, and low-level laser light therapy effectively treat hair loss.

research Topical Minoxidil: Systematic Review and Meta-Analysis of Its Efficacy in Androgenetic Alopecia

12 citations , May 2015 in “PubMed”

research Hair Growth-Promoting Effects of Adiponectin In Vitro

22 citations , December 2012 in “Journal of Investigative Dermatology”

Adiponectin may stimulate hair growth and could be a potential treatment for promoting hair growth.

research Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells

66 citations , June 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Adenosine may promote hair growth by increasing FGF-7 levels in dermal papilla cells.

research Hair Cycle-Specific Expression of Versican in Human Hair Follicles

88 citations , September 2005 in “Journal of Dermatological Science”

Versican, a protein, is less present in thinning hair follicles and this decrease might contribute to common hair loss in men.

research A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss

219 citations , April 2004 in “Journal of The American Academy of Dermatology”

5% and 2% minoxidil solutions effectively promote hair growth and reduce hair loss, with 5% being slightly more effective but having more side effects.

research Minoxidil: Mechanisms of Action on Hair Growth

397 citations , February 2004 in “British Journal of Dermatology”

Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

520 citations , February 2001 in “Journal of Clinical Investigation”

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

research Treatment of Hair Loss

370 citations , September 1999 in “The New England Journal of Medicine”

Finasteride and minoxidil are effective for hair loss, but continued research is needed for better treatments.

research Finasteride

125 citations , January 1999 in “Drugs”

Finasteride effectively treats baldness but may cause sexual side effects.

research Finasteride

187 citations , January 1994 in “The New England Journal of Medicine”

Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.

research Melanogenesis is coupled to murine anagen: Toward new concepts for the role of melanocytes and the regulation of melanogenesis in hair growth

210 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair color production in mice is closely linked to the hair growth phase and may also influence hair growth itself.