TLDR Dimeric peptide derivatives could help hair growth and treat hair loss safely.
The study synthesized and evaluated dimeric peptide derivatives for their effects on the proliferation of human follicle dermal papilla cells (HFDPCs) in vitro. These derivatives stimulated HFDPC proliferation more effectively than the tripeptide Arg-His-Lys (AHK). Specifically, peptide No. 20 (Arg-Trp-Lys, AWK') significantly promoted the phosphorylation of ERK1/2 and activated the mRNA expression of hair regeneration-related genes such as VEGF, FGF-2, and FGF-7. The findings suggest that dimeric peptide derivatives could be promising agents for hair regeneration and alopecia treatment, acting through ERK1/2 signaling without significant cytotoxicity.
136 citations,
May 2019 in “Cells” Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.
76 citations,
August 2018 in “International Journal of Cosmetic Science” Dermal Papilla cells are a promising tool for evaluating hair growth treatments.
19 citations,
May 2016 in “Clinical, cosmetic and investigational dermatology” FGF-2&D/P nanoparticles can help treat hair loss.
165 citations,
January 2008 in “Journal of biomaterials science. Polymer ed.” The peptide GHK-Cu helps heal and remodel tissue, improves skin and hair health, and has potential for treating age-related inflammatory diseases.
39 citations,
July 2007 in “Archives of Pharmacal Research” A tripeptide-copper complex may help hair grow by increasing cell growth and decreasing cell death.
56 citations,
July 2005 in “Experimental Dermatology” Injected human hair follicle cells can create new, small hair follicles in skin cultures.
26 citations,
January 2016 in “Annals of Dermatology” Ecklonia cava polyphenols help increase human hair growth and reduce hair loss.
August 2022 in “International journal of research in pharmacy and chemistry” Teak is a durable, termite-resistant wood with medicinal benefits.
August 2024 in “Applied Sciences” Plant extracts may help prevent or reverse hair graying.
9 citations,
August 2005 in “Experimental Dermatology” Modified pep7, named EPM peptide, effectively promotes hair growth at low concentrations and works well with minoxidil.
451 citations,
March 2005 in “Endocrine Reviews” The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.
