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Glossary Phosphorylation of ERK

process activating ERK protein by adding phosphate groups

Phosphorylation of ERK, also known as ERK activation, refers to the process where the extracellular signal-regulated kinase (ERK) protein is activated by the addition of phosphate groups. This activation is a crucial step in the MAPK/ERK signaling pathway, which transmits signals from the cell surface to the DNA in the cell nucleus, influencing cell functions such as division, differentiation, and survival. This process is significant in various biological contexts, including hair growth and the response to stress or injury.

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research Trichosanthes kirilowii Extract Promotes Wound Healing through the Phosphorylation of ERK1/2 in Keratinocytes

16 citations , October 2022 in “Biomimetics”

This study found that Trichosanthes kirilowii extract significantly enhances keratinocyte proliferation and wound healing in vitro and in vivo, suggesting its potential as a wound-healing component.

research Interleukin-25-Mediated-IL-17RB Upregulation Promotes Cutaneous Wound Healing in Diabetic Mice by Improving Endothelial Cell Functions

34 citations , January 2022 in “Frontiers in Immunology”

This study found that IL-25-mediated-IL-17RB signaling improved diabetic wound healing by enhancing angiogenesis, collagen deposition, and endothelial cell function, suggesting a potential therapeutic strategy for poorly healing diabetic wounds.

research VEGF165 modulates proliferation, adhesion, migration and differentiation of cultured human outer root sheath cells from central hair follicle epithelium through VEGFR-2 activation in vitro

35 citations , October 2013 in “Journal of Dermatological Science”

This study observed that VEGF165 increases proliferation and migration but alters adhesion properties of cultured human hair follicle cells, indicating a potential role for VEGF/VEGFR-2 in hair follicle regulation beyond angiogenesis.

research Synthesis and biological evaluation of dimeric peptide derivatives as proliferation‐stimulating agents in human follicle dermal papilla cells

3 citations , September 2021 in “Bulletin of the Korean Chemical Society”

In this study, dimeric peptide derivatives were shown to enhance the proliferation of human follicle dermal papilla cells in vitro, particularly promoting the ERK1/2 pathway, suggesting potential for developing peptide-based treatments for hair regeneration.

research The Additive Effects of Minoxidil and Retinol on Human Hair Growth in Vitro

32 citations , January 2007 in “Biological & Pharmaceutical Bulletin”

This study found that combining minoxidil and retinol additively promoted hair growth in vitro, enhancing Erk- and Akt-dependent pathways and preventing apoptosis in dermal papilla cells and keratinocytes.

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