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    Glossary Tyrosine Kinase

    enzyme that transfers phosphate groups to tyrosine on proteins

    Tyrosine Kinase (TK) is an enzyme that functions by transferring a phosphate group from ATP to a specific amino acid called tyrosine on a protein. This process, known as phosphorylation, is crucial for regulating various cellular activities, including cell division, growth, and signaling pathways. Dysregulation of tyrosine kinases can lead to diseases such as cancer, making them important targets for certain therapeutic drugs.

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    1. Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects Current drug metabolism · 2009 · 508 citations
    2. Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases Frontiers in immunology · 2019 · 88 citations
    3. Tyrosine kinase inhibition and grey hair The Lancet · 2003 · 59 citations
    4. Unique Cutaneous Reaction to Second- and Third-Generation Tyrosine Kinase Inhibitors for Chronic Myeloid Leukemia Dermatology · 2015 · 32 citations
    5. Adverse cutaneous reactions to the new second-generation tyrosine kinase inhibitors (dasatinib, nilotinib) in chronic myeloid leukemia Journal of the American Academy of Dermatology · 2013 · 25 citations
    6. Efficacy and safety of the oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family kinase inhibitor ritlecitinib over 24 months: integrated analysis of the ALLEGRO phase IIb/III and long-term phase III clinical studies in alopecia areata British Journal of Dermatology · 2024 · 23 citations
    7. A Case of Inflammatory Nonscarring Alopecia Associated With the Tyrosine Kinase Inhibitor Nilotinib JAMA Dermatology · 2013 · 16 citations
    8. Expression Profiles of Tyrosine Kinases in Cultured Follicular Papilla Cells Versus Dermal Fibroblasts Journal of Investigative Dermatology · 2004 · 11 citations
    9. Repigmentation of leukoderma in a piebald patient associated with a novel c-KIT gene mutation, G592E, of the tyrosine kinase domain Journal of Dermatological Science · 2011 · 6 citations
    10. 265 Modulation of disease-central cytokine pathways with TAK-279, a highly selective oral tyrosine kinase 2 (TYK2) inhibitor, defines clinical response in patients with psoriasis Journal of Investigative Dermatology · 2024 · 1 citations
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    Learn 2

    1. L-Tyrosine HCL
    2. Acetyl Tyrosine

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