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    Glossary Tyrosine Kinase

    enzyme that transfers phosphate groups to tyrosine on proteins

    Tyrosine Kinase (TK) is an enzyme that functions by transferring a phosphate group from ATP to a specific amino acid called tyrosine on a protein. This process, known as phosphorylation, is crucial for regulating various cellular activities, including cell division, growth, and signaling pathways. Dysregulation of tyrosine kinases can lead to diseases such as cancer, making them important targets for certain therapeutic drugs.

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    1. Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects Current drug metabolism · 2009 · 508 citations
    2. Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases Frontiers in immunology · 2019 · 88 citations
    3. Tyrosine kinase inhibition and grey hair The Lancet · 2003 · 59 citations
    4. Unique Cutaneous Reaction to Second- and Third-Generation Tyrosine Kinase Inhibitors for Chronic Myeloid Leukemia Dermatology · 2015 · 32 citations
    5. Adverse cutaneous reactions to the new second-generation tyrosine kinase inhibitors (dasatinib, nilotinib) in chronic myeloid leukemia Journal of the American Academy of Dermatology · 2013 · 25 citations
    6. Efficacy and safety of the oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family kinase inhibitor ritlecitinib over 24 months: integrated analysis of the ALLEGRO phase IIb/III and long-term phase III clinical studies in alopecia areata British Journal of Dermatology · 2024 · 23 citations
    7. A Case of Inflammatory Nonscarring Alopecia Associated With the Tyrosine Kinase Inhibitor Nilotinib JAMA Dermatology · 2013 · 16 citations
    8. Expression Profiles of Tyrosine Kinases in Cultured Follicular Papilla Cells Versus Dermal Fibroblasts Journal of Investigative Dermatology · 2004 · 11 citations
    9. Repigmentation of leukoderma in a piebald patient associated with a novel c-KIT gene mutation, G592E, of the tyrosine kinase domain Journal of Dermatological Science · 2011 · 6 citations
    10. 265 Modulation of disease-central cytokine pathways with TAK-279, a highly selective oral tyrosine kinase 2 (TYK2) inhibitor, defines clinical response in patients with psoriasis Journal of Investigative Dermatology · 2024 · 1 citations
    11. Tyrosine kinase Inhibitors in Dermatology: A Systemic Review Journal of dermatology and dermatitis · 2021 · 1 citations
    12. Characterisation, genomic organisation, expression and function of the mEphA1 receptor Tyrosine Kinase 2007
    13. Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, in patients with alopecia areata: efficacy and safety results of a phase II, multicenter, randomized, double-blinded, placebo-controlled trial British Journal of Dermatology · 2026
    14. Cutaneous Adverse Events of Tyrosine Kinase Inhibitors in Endocrine Tumors: Clinical Features, Mechanisms, and Management Strategies Biomedicines · 2025
    15. Keratosis Pilaris-like Eruption during Treatment of Chronic Myeloid Leukemia with Tyrosine Kinase Inhibitors: Literature Review and Report of a Case Related to Imatinib Journal of clinical medicine · 2023
    16. 27 Preclinical ex vivo and in vivo evidence supporting selective inhibition of tyrosine kinase 2-dependent, IL-12-mediated signaling as a novel pharmacological strategy for alopecia areata management 2023
    17. 014 Tyrosine Kinase 2 Inhibition Ameliorates the Phenotype of Lesional Alopecia Areata Scalp Skin Ex Vivo, and Reverses the Induction of Human Alopecia Areata in a Humanized Mouse Model 2022
    18. 700 Tyrosine kinase 2 inhibition rescues hair follicles from IL-12–mediated immune privilege collapse and reverses the induction of human alopecia areata in a humanized mouse model Journal of Investigative Dermatology · 2022
    19. 061 Selective inhibition of tyrosine kinase 2 prevents and restores interleukin-12-induced hair follicle immune privilege collapse: a novel approach to alopecia areata therapy? Journal of Investigative Dermatology · 2021
    20. Tyrosine Kinase Inhibitors against Cancer: Their Safety in 216 Moroccan Patients Journal of Cancer Therapy · 2021
    21. Effets secondaires cutanéo-muqueux des nouvelles molécules anticancéreuses: Inhibiteurs de l'EGF-R, inhibiteurs de tyrosine kinase et stabilisateurs du fuseau mitotique 2011
    22. Skin stem cells and tumor growth : functions of collagen XVIII in hair follicle cycling and skin cancer, and Bmx tyrosine kinase in tumor angiogenesis 2014 · 3 citations
    23. Receptor tyrosine kinase Kit action in skin melanocytes: is it exclusively cell autonomous? Experimental Dermatology · 2015 · 1 citations
    24. Bioinformatic analysis of gene expression data reveals Src family protein tyrosine kinases as key players in androgenetic alopecia Frontiers in Medicine · 2023
    25. 078 The transmembrane protein LRIG1 regulates receptor tyrosine kinases in skin development and homeostasis Journal of Investigative Dermatology · 2017
    26. Safety Profile of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: A Disproportionality Analysis of FDA Adverse Event Reporting System Scientific Reports · 2020 · 58 citations
    27. Safety of Tyrosine Kinase Inhibitors in Patients With Differentiated Thyroid Cancer: Real-World Use of Lenvatinib and Sorafenib in Korea Frontiers in Endocrinology · 2019 · 39 citations
    28. Taiwanese Dermatological Association consensus for the prevention and management of epidermal growth factor receptor tyrosine kinase inhibitor-related skin toxicities Journal of the Formosan Medical Association · 2017 · 22 citations
    29. Acneiform eruptions caused by an epidermal growth factor receptor-tyrosine kinase inhibitor ZD 1839 Journal of the American Academy of Dermatology · 2004 · 1 citations
    30. Platycladus orientalis Leaf Extract Promotes Hair Growth via Non-Receptor Tyrosine Kinase ACK1 Activation Current Issues in Molecular Biology · 2024