TLDR The genetic variant studied does not affect PCOS symptoms in Kashmiri women.
The study examined the association of the His1058 C/T SNP (rs1799817) polymorphism in the insulin receptor gene with PCOS in 349 Kashmiri women, including 249 with PCOS and 100 controls. It found no significant association between the SNP and PCOS, as allele and genotype frequencies were similar between cases and controls. The study concluded that this genetic variant did not significantly impact clinical manifestations of hyperandrogenism, ovulatory dysfunction, or metabolic parameters in Kashmiri women with PCOS. Although the T allele was linked to increased insulin resistance in a subphenotype, it did not significantly affect overall clinical presentations. The study noted limitations such as insufficient control numbers and potential selection bias.
49 citations,
November 2019 in “Egyptian Journal of Medical Human Genetics” Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.
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17 citations,
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4025 citations,
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15 citations,
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212 citations,
May 2010 in “American Journal of Obstetrics and Gynecology” Diagnosing PCOS in teenagers is challenging and should use strict criteria to avoid misdiagnosis and unnecessary worry.
4809 citations,
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