Tyrosine Kinase Inhibitors in Dermatology: A Systematic Review

June 2021 in “ Journal of dermatology and dermatitis ”

Piyu Parth Naik

tyrosine kinase inhibitors TKIs alopecia areata psoriasis vitiligo atopic dermatitis lupus inflammatory skin disorders immune-mediated skin disorders

TLDR Tyrosine kinase inhibitors show promise in treating some skin diseases but their definitive role in dermatology is still unclear.

Tyrosine kinase inhibitors (TKIs) are a class of drugs that have shown promise in treating various skin diseases by blocking the action of certain enzymes. This review article examines the effectiveness of TKIs in dermatology, highlighting their successful use in conditions like psoriasis, alopecia areata, and vitiligo, and a variable response in others such as atopic dermatitis and lupus. While TKIs have generated significant interest for their potential to improve the treatment of inflammatory and immune-mediated skin disorders, the review suggests that it is still too early to definitively determine their role in dermatological therapy, despite the encouraging evidence.

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