Tyrosine Kinase Inhibitors: A Review on Pharmacology, Metabolism, and Side Effects
June 2009
in “
Current drug metabolism
”
tyrosine kinase inhibitors TKIs imatinib gefitinib erlotinib sorafenib sunitinib dasatinib folliculitis paronychia facial hair growth erythema frontal alopecia VEGFR PDGFR FLT3 periorbital edema hypothyroidism Gleevec Iressa Tarceva Nexavar Sutent Sprycel hair follicle inflammation nail infection redness hair loss vascular endothelial growth factor receptor platelet-derived growth factor receptor FMS-like tyrosine kinase 3 swelling around the eyes underactive thyroid
Studysummary This review details the skin and hematological toxicities of tyrosine kinase inhibitors like erlotinib, gefitinib, and imatinib, and highlights ongoing concerns about cardiac toxicity, reporting no new clinical findings.
Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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