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GlossaryTropomyosin receptor kinase A

receptor protein involved in nerve growth and hair follicle health

Tropomyosin receptor kinase A (TrkA) is a protein that plays a crucial role in the development and function of the nervous system. It is a receptor for nerve growth factor (NGF), which is essential for the survival, growth, and maintenance of certain types of neurons. TrkA is also involved in pain perception and can influence hair growth by affecting the health of hair follicles.

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Optogenetically Controlled TrkA Activity Improves the Regenerative Capacity of Hair-Follicle-Derived Stem Cells to Differentiate into Neurons and Glia

research Optogenetically Controlled TrkA Activity Improves the Regenerative Capacity of Hair-Follicle-Derived Stem Cells to Differentiate into Neurons and Glia

6 citations, September 2020 in “Advanced Biology”

Blue-light activation of TrkA improves hair-follicle stem cells' ability to become neurons and glial cells.

Neurotrophin-4 Modulates the Mechanotransducer Cav3.2 T-Type Calcium Current in Mice Down-Hair Neurons

research Neurotrophin-4 Modulates the Mechanotransducer Cav3.2 T-Type Calcium Current in Mice Down-Hair Neurons

11 citations, December 2011 in “Biochemical journal”

Neurotrophin-4 increases calcium current in specific mouse neurons through the PI3K pathway.

Janus Kinase (JAK) Inhibitors for the Treatment of Skin and Hair Disorders: A Review of Literature

research Janus Kinase (JAK) Inhibitors for the Treatment of Skin and Hair Disorders: A Review of Literature

40 citations, December 2016 in “Journal of Dermatological Treatment”

JAK inhibitors show promise for treating skin and hair disorders but need more research on long-term safety and effectiveness.

research Age-Associated Decrease in GDNF and Its Cognate Receptor GFRα-1 Protein Expression in Human Skin

2 citations, June 2016 in “International journal of experimental pathology”

Human skin has less GDNF and its receptor with age.

research Nerve Growth Factor Regulates the Proliferation of Cashmere Goat Outer Root Sheath Cells Through the Activation of cAMP-Binding Protein

1 citations, July 2019 in “Small ruminant research”

Nerve growth factor helps cashmere goat hair cells grow by activating a specific protein.

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