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    Glossary Tropomyosin receptor kinase A

    receptor protein involved in nerve growth and hair follicle health

    Tropomyosin receptor kinase A (TrkA) is a protein that plays a crucial role in the development and function of the nervous system. It is a receptor for nerve growth factor (NGF), which is essential for the survival, growth, and maintenance of certain types of neurons. TrkA is also involved in pain perception and can influence hair growth by affecting the health of hair follicles.

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    1. Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1 Frontiers in Cell and Developmental Biology · 2020 · 3 citations
    2. Age‐associated decrease in GDNF and its cognate receptor GFRα‐1 protein expression in human skin International journal of experimental pathology · 2016 · 2 citations
    3. Netherton syndrome subtypes share IL-17/IL-36 signature with distinct IFN-α and allergic responses Journal of Allergy and Clinical Immunology · 2021 · 59 citations
    4. S100 signaling in hair follicle biology: emerging mechanistic insights and therapeutic opportunities Journal of Molecular Histology · 2026
    5. S100A6 Protein—Expression and Function in Norm and Pathology International Journal of Molecular Sciences · 2023 · 21 citations
    6. RAGE and Its Ligands in Melanoma InTech eBooks · 2015 · 1 citations
    7. Pubertal hormones increase hippocampal expression of α4βδ GABAA receptors Neuroscience letters · 2019 · 5 citations
    8. Identification of hepatic molecular mechanisms of action of alpha-tocopherol using global gene expression profile analysis in rats Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2004
    9. Emerging Roles for Ion Channels in Ovarian Cancer: Pathomechanisms and Pharmacological Treatment Cancers · 2021 · 29 citations
    10. Proteomic analysis of balding and non-balding mesenchyme-derived dermal papilla cells from androgenetic alopecia patients using on-line two-dimensional reversed phase-reversed phase LC–MS/MS Journal of Proteomics · 2013 · 11 citations
    11. Therapeutic Potential of Nerve Growth Factor-Modified Hair Follicle Stem Cells Transplantation in a Rat Model of Alzheimer’s Disease Journal of Integrative Neuroscience · 2026
    12. Current Perspectives on the Physiological Activities of Fermented Soybean-Derived Cheonggukjang International Journal of Molecular Sciences · 2021 · 26 citations
    13. The senescence-like activity of BMS-470539 is associated with anti-fibrotic actions in models of dermal fibrosis Arthritis Research & Therapy · 2025
    14. Impacto del desequilibrio del microbioma del cuero cabelludo en la severidad de la alopecia areata, marcadores inflamatorios y cambios post-tratamiento Universidad de Córdoba Insitutional Repository (Universidad de Córdoba) · 2025
    15. Nerve growth factor regulates the proliferation of cashmere goat outer root sheath cells through the activation of cAMP-binding protein Small ruminant research · 2019 · 1 citations
    16. Integrating Psychological Support and Topical Therapy for the Effective Management of Stress-Induced Alopecia Areata: A Case Report Cureus · 2025
    17. Oral Administration of TrkB Agonist, 7, 8–Dihydroxyflavone Regenerates Hair Cells and Restores Function after Gentamicin–Induced Vestibular Injury in Guinea Pig Pharmaceutics · 2023
    18. Efficacy of spironolactone as adjunctive therapy to sodium valproate in bipolar‐I disorder: A double‐blind, randomized, placebo‐controlled clinical trial Brain and behavior · 2023 · 1 citations
    19. The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds Cells · 2023 · 9 citations
    20. Effects of Curcumin and Its Different Formulations in Preclinical and Clinical Studies of Peripheral Neuropathic and Postoperative Pain: A Comprehensive Review International Journal of Molecular Sciences · 2021 · 46 citations
    21. 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) from Polygonum multiflorum Thunb.: A Systematic Review on Anti-Aging International Journal of Molecular Sciences · 2025 · 3 citations
    22. Psychological Stress-Induced Pathogenesis of Alopecia Areata: Autoimmune and Apoptotic Pathways International journal of molecular sciences · 2023 · 3 citations
    23. The Potential Reversible Transition between Stem Cells and Transient-Amplifying Cells: The Limbal Epithelial Stem Cell Perspective Cells · 2024 · 1 citations
    24. Natural products and their derivatives as candidate treatments for hair greying: from drug discovery to molecular mechanisms Chinese Medicine · 2026
    25. Transcranial photobiomodulation for brain diseases: review of animal and human studies including mechanisms and emerging trends Neurophotonics · 2024
    26. The regulation of skin homeostasis, repair and the pathogenesis of skin diseases by spatiotemporal activation of epidermal mTOR signaling Frontiers in Cell and Developmental Biology · 2022 · 35 citations
    27. Inflammatory bowel disease: pathogenesis, diagnosis and current therapeutic approach Journal of Mind and Medical Sciences · 2022 · 13 citations
    28. Extracellular vesicles in age-related diseases: disease pathogenesis, intervention, and biomarker Stem Cell Research & Therapy · 2025 · 9 citations
    29. Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment Development · 2003 · 182 citations
    30. Extracellular Vesicles in Osteogenesis: A Comprehensive Review of Mechanisms and Therapeutic Potential for Bone Regeneration Current Issues in Molecular Biology · 2025 · 9 citations