Platycladus Orientalis Leaf Extract Promotes Hair Growth Via Non-Receptor Tyrosine Kinase ACK1 Activation

October 2024 in “ Current Issues in Molecular Biology ”

Jaeyoon Kim, Jang Ho Joo, Juhyun Kim, Heena Rim, Jae Young Shin, Yun-Ho Choi, Kyung-Jin Min, So Young Lee, Seung‐Hyun Jun, Nae‐Gyu Kang

Studysummary In this experimental study, the researchers observed that Platycladus orientalis leaf extract promoted hair growth by enhancing dermal papilla cell proliferation and increasing growth factor expression, particularly through ACK1 activation and modulation of Wnt/β-catenin signaling pathways in cultured human cells and a 12-week topical application.

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The study examines the effects of Platycladus orientalis leaf extract (POLE) on hair growth, particularly through the activation of non-receptor tyrosine kinase ACK1. POLE enhances cell viability and proliferation in human dermal papilla cells (hDPCs) by modulating mRNA and protein expression related to cell proliferation and senescence. It activates growth factor receptors and the Wnt/β-catenin signaling pathway, leading to increased production of growth factors like bFGF, KGF, and VEGF. In a clinical trial with 60 participants, a 1% POLE solution significantly increased terminal hair density by +4.01 hairs/cm² over 12 weeks compared to a placebo. These results suggest that POLE could be a promising therapeutic agent for hair growth and hair loss prevention.

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