Phytochemicals as Emerging Therapeutic Agents for Alopecia Treatment

January 2020 in “ Elsevier eBooks ”

A. Premanand, V P Ancy, Jaison Jeevanandam, B. Reena Rajkumari, Michael K. Danquah

phytochemicals alopecia minoxidil finasteride dutasteride hair loss plant-based formulations Wnt/ß-catenin pathway herbs active compounds hair growth signaling pathways in vitro in vivo Rogaine Propecia

From the encyclopedia

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Finasteride →

Frontline, gold standard treatment for combatting androgenic alopecia

Dutasteride →

Heavy duty finasteride that comes with higher risks

Studysummary This chapter provides an overview of phytochemicals with properties to combat alopecia and discusses the potential of flavonoids, found in several herbs, as a safer alternative to synthetic hair loss treatments due to their long-term skin compatibility.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document from 2020 examines the potential of phytochemicals as alternative treatments for alopecia, comparing them to conventional therapies like minoxidil, finasteride, and dutasteride, which have various side effects and limitations. It outlines the historical use of plant-based formulations for hair loss and recent advancements in phytochemical research. The document details the effects of phytochemicals on hair growth-related signaling pathways, such as the Wnt/ß-catenin pathway, and lists various herbs and their active compounds that have shown promising results in promoting hair growth in animal models. It categorizes phytochemicals based on their chemical groups and suggests that combinations of these compounds may be more effective. The conclusion emphasizes the need for better documentation and understanding of the mechanisms of phytochemicals to make them competitive with conventional treatments, noting that they have shown potential in in vitro and in vivo studies to increase hair growth and prevent alopecia.

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14 citations , January 2006 in “Skin pharmacology and physiology”

This study found that procyanidin oligomers from apples and barley may stimulate hair growth by promoting hair epithelial cell proliferation and protecting them from apoptosis via MEK activation in a murine model.

research The Hair Growth Promoting Effect of Asiasari Radix Extract and Its Molecular Regulation

87 citations , March 2005 in “Journal of Dermatological Science”

This study found that the extract of Asiasari radix may promote hair growth in mice by enhancing protein synthesis, cell proliferation, and growth factor expression.

research Placebo-Controlled Oral Pulse Prednisolone Therapy in Alopecia Areata

141 citations , February 2005 in “Journal of the American Academy of Dermatology”

In this study, oral prednisolone pulse therapy led to significant hair regrowth in some patients with extensive alopecia areata, whereas no improvement was seen in the placebo group.

research Epidermal Growth Factor as a Biological Switch in Hair Growth Cycle

94 citations , July 2003 in “Journal of biological chemistry/The Journal of biological chemistry”

This study found that continuous expression of epidermal growth factor in transgenic mice prevented hair follicles from entering the catagen phase, implicating EGF as a crucial regulator in hair cycle progression.

research PUVA Treatment of Alopecia Areata Totalis and Universalis: A Retrospective Study

39 citations , April 2003 in “Australasian journal of dermatology”

This study found that PUVA treatment resulted in complete hair regrowth in over half of patients with alopecia areata totalis or universalis, despite a higher treatment failure rate in those with a family history of the condition.

research The Extract of Thuja Occidentalis Semen Inhibited 5α-Reductase and Androgenetic Alopecia in B6CBAF1/J Hybrid Mice

47 citations , April 2003 in “Journal of dermatological science”

This study showed that Thujae occidentalis semen extract inhibited 5alpha-reductase type 2 in laboratory tests and reduced androgen-related hair loss in animal models, suggesting potential use for male pattern baldness.

Procyanidin B-3, Isolated from Barley and Identified as a Hair-Growth Stimulant, Has the Potential to Counteract Inhibitory Regulation by TGF-β1

research Procyanidin B-3, Isolated from Barley and Identified as a Hair-Growth Stimulant, Has the Potential to Counteract Inhibitory Regulation by TGF-β1

36 citations , December 2002 in “Experimental dermatology”

This study found that procyanidin B-3, a compound isolated from barley extract, may promote hair growth by enhancing hair epithelial cell growth and counteracting TGF-β1's growth-inhibiting effects in vitro and in vivo.

research Androgenetic Alopecia: Pathogenesis and Potential for Therapy

174 citations , November 2002 in “Expert Reviews in Molecular Medicine”

This review discusses the genetic factors contributing to androgenetic alopecia and highlights the potential for developing more effective therapies based on recent discoveries, but reports no new clinical results.

research Telogen Effluvium: Causes, Diagnosis, and Treatment

144 citations , July 2002 in “Clinical and Experimental Dermatology”

This article reviews the concept of telogen effluvium and emphasizes the importance of identifying triggers and using diagnostic investigations to determine the cause of hair loss, without reporting new results.

research Procyanidin B-2 Extracted from Apples Promotes Hair Growth: A Laboratory Study

37 citations , January 2002 in “British journal of dermatology/British journal of dermatology, Supplement”

This study found that procyanidin B-2 may promote hair growth by reducing expression and inhibiting translocation of PKC isozymes in murine hair epithelial cells.

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

520 citations , February 2001 in “Journal of Clinical Investigation”

This study found that VEGF significantly enhances perifollicular vascularization during the hair growth phase, accelerating hair regrowth and increasing follicle and hair size, while its inhibition retards hair growth.

research Treatments for Androgenetic Alopecia and Alopecia Areata

72 citations , January 2001 in “Drugs”

This review discusses current and emerging drug therapies for treating androgenetic alopecia and alopecia areata, and reports no clinical results; it highlights a need for improved and novel treatments.

research Hair Loss in Psychopharmacology

63 citations , March 2000 in “Annals of clinical psychiatry”

This article reviews the association between psychopharmaceuticals and medication-induced alopecia, noting that hair regrowth typically occurs after discontinuing or reducing the medication, while mineral supplements' effectiveness remains unclear.

research Insulin-Like Growth Factor 1 and Hair Growth

98 citations , November 1999 in “Dermatology Online Journal”

This review discusses the effects of IGF-1 on hair follicle cell proliferation and differentiation, highlighting its roles in paracrine signaling, apoptosis prevention, and hair growth, but reports no new clinical results.

research Proanthocyanidins from Grape Seeds Promote Proliferation of Mouse Hair Follicle Cells In Vitro and Convert Hair Cycle In Vivo

64 citations , October 1998 in “Acta dermato-venereologica”

This study found that proanthocyanidins from grape seeds significantly promote hair follicle cell proliferation and hair cycle transition in mice, suggesting their potential as hair growth agents.

research Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells

192 citations , March 1998 in “British Journal of Dermatology”

This study found that minoxidil significantly increases VEGF mRNA and protein expression in dermal papilla cells, suggesting a role in enhancing hair follicle vascularization in androgenetic alopecia.

research Follicular Transplantation: Patient Evaluation and Surgical Planning

29 citations , September 1997 in “PubMed”

This paper reviews follicular hair transplantation techniques and planning, emphasizing careful evaluation and long-term strategy for achieving excellent cosmetic results.

research Fibroblast Growth Factor and Epidermal Growth Factor in Hair Development

39 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that daily injections of basic and acidic fibroblast growth factor in newborn mice significantly delayed hair follicle development within the treatment area, while epidermal growth factor affected the entire body coat and caused skin hyperkeratinization.

research The Comparative Histopathology of Male-Pattern Baldness and Senescent Baldness

143 citations , October 1988 in “Clinics in Dermatology”

This review discusses the histopathology of male-pattern baldness and highlights ongoing disputes over several aspects, including sebaceous gland size and follicle loss, reporting no new clinical findings.

research Male Pattern Alopecia: A Histopathologic and Histochemical Study

94 citations , August 1975 in “Journal of Cutaneous Pathology”

In this study, the researchers observed that male pattern alopecia is characterized by miniature follicles, enlarged sebaceous glands, and an increased number of mast cells, without significant abnormalities in enzyme activity.