Phytochemicals as Emerging Therapeutic Agents for Alopecia Treatment

The document from 2020 examines the potential of phytochemicals as alternative treatments for alopecia, comparing them to conventional therapies like minoxidil, finasteride, and dutasteride, which have various side effects and limitations. It outlines the historical use of plant-based formulations for hair loss and recent advancements in phytochemical research. The document details the effects of phytochemicals on hair growth-related signaling pathways, such as the Wnt/ß-catenin pathway, and lists various herbs and their active compounds that have shown promising results in promoting hair growth in animal models. It categorizes phytochemicals based on their chemical groups and suggests that combinations of these compounds may be more effective. The conclusion emphasizes the need for better documentation and understanding of the mechanisms of phytochemicals to make them competitive with conventional treatments, noting that they have shown potential in in vitro and in vivo studies to increase hair growth and prevent alopecia.