The Potential of Androgenic Alopecia Management from Plant Derivatives

In 2020, a study explored the potential of using plant derivatives to manage androgenic alopecia, a common type of hair loss. The research identified that androgenic alopecia is often due to high production of dihydrotestosterone (DHT), with the 5a-reductase Type-2 enzyme playing a significant role in this process. Genetic factors, specifically variations in the androgen receptor (AR) gene, were also identified as potential causes. While synthetic drugs like minoxidil and finasteride were discussed, their side effects were noted. The study highlighted the potential of plant derivatives, such as Avicennia marina, Boehmeria nipononivea, and Camellia sinensis, as alternative treatments with fewer side effects. These plants showed potential in inhibiting 5a-reductase and reducing hair loss. The study also discussed the potential of using nanoparticles as a delivery system for these plant derivatives. However, more clinical trials were needed to confirm these findings.