Effects of Ginseng Rhizome and Ginsenoside Ro on Testosterone 5α-Reductase and Hair Regrowth in Testosterone-Treated Mice

    May 2011 in “ Phytotherapy Research ”
    Kazuya Murata, Fumiaki Takeshita, Keiichi Samukawa, Tohru Tani, Hideaki Matsuda
    Image of study
    TLDR Ginseng, especially red ginseng, may help regrow hair and block a hair loss-related enzyme.
    The study from 2011 examined the potential of ginseng rhizome extracts, particularly from red ginseng (RG), and ginsenoside Ro in promoting hair re-growth and inhibiting testosterone 5α-reductase (5αR), an enzyme involved in androgenetic alopecia. The extracts showed dose-dependent 5αR inhibitory effects, with white ginseng (WG) showing the highest inhibition at 68.9% at 1000 µg/mL. Ginsenoside Ro had an IC50 value of 259.4 µM, while ginsenoside Rg3, also found in RG, had an IC50 value of 86.1 µM, indicating strong inhibitory activity. Topical application of these substances on testosterone-treated C57BL/6 mice prevented the suppression of hair re-growth normally caused by testosterone. The study concluded that RG rhizome extracts, rich in ginsenoside Ro, could be effective in hair re-growth products for androgenetic alopecia. This was the first demonstration of ginsenoside Ro's in vivo hair re-growth effects. The number of mice used in the hair re-growth test was 10 per group.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results

    Related Community Posts Join

    6 / 35 results

      community Lavdik Hair Growth Serum?

      in Product 4 years ago
      A user is concerned about the legitimacy of a hair growth serum called Lavdik, which they ordered after seeing an ad for Jemros. The product contains ginger extract, ginseng extract, fleece flower root, grape seed oil, glycerol, carbomer, propylene glycol, and rosemary oil, and the user is unsure if it is effective or a scam.

      community How to make topical melatonin?

      in Treatment  1 upvotes 10 months ago
      The conversation is about creating a topical melatonin treatment for hair loss. Specific treatments discussed include Minoxidil, Finasteride, and RU58841.

      community Unexpected hairline re-growth (taking new supplements)

      in Treatment  32 upvotes 3 years ago
      A user in their mid-30s experienced unexpected hairline regrowth after starting a new supplement stack, despite being on a regimen of finasteride, minoxidil, and Nizoral for over four years. The new supplements include Tongkat Ali, Fadogia Agrestis, Panax Red Ginseng, Vitamin B1, Vitamin D3, Zinc Picolinate, Magnesium Glycinate, Maca, and L-Citrulline.

    Related Research

    1 / 1 results