Exogenous Stimulation with Eclipta Alba Promotes Hair Matrix Keratinocyte Proliferation and Downregulates TGF-β1 Expression in Nude Mice

    Shahnaz Begum, Mi Ra Lee, Li Gu … Chang‐Keun Sung
    Studysummary In this study, researchers found that petroleum ether extract of Eclipta alba significantly stimulated follicular keratinocyte proliferation and reduced TGF-β1 expression in nude mice, suggesting potential use for certain types of alopecia.
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    Research cited in this study 13

    1. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    2. Evaluation of Hydro-Alcoholic Extract of Eclipta Alba for Its Anticancer Potential: An In Vitro Study Journal of Ethnopharmacology · 2011
    3. Eclipta Alba Extract With Potential For Hair Growth Promoting Activity Journal of Ethnopharmacology · 2009
    4. Hair Growth Promoting Activity of Eclipta Alba in Male Albino Rats Archives of Dermatological Research · 2008
    5. Learning From Nudity: Lessons From The Nude Phenotype Experimental Dermatology · 2005
    6. Hair Growth Induction by the Tellurium Immunomodulator AS101: Association with Delayed Terminal Differentiation of Follicular Keratinocytes and Ras-Dependent Up-Regulation of KGF Expression The FASEB Journal · 2003
    7. Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes American Journal of Physiology-cell Physiology · 2003
    8. Forkhead/Winged-Helix Transcription Factor Whn Regulates Hair Keratin Gene Expression: Molecular Analysis of the Nude Skin Phenotype Developmental Dynamics · 2000
    9. Principles of Hair Cycle Control The Journal of Dermatology · 1998
    10. Molecular and Functional Aspects of the Hairless (Hr) Gene in Laboratory Rodents and Humans Experimental Dermatology · 1998
    11. Transforming Growth Factor-β Receptor Type I and Type II Expression During Murine Hair Follicle Development and Cycling Journal of Investigative Dermatology · 1997
    12. Effect of Cyclosporin on Hair-Existing Area of Nude Mice Journal of Dermatological Science · 1994
    13. The Secret Life of the Hair Follicle Trends in genetics · 1992

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