Exogenous Stimulation with Eclipta Alba Promotes Hair Matrix Keratinocyte Proliferation and Downregulates TGF-β1 Expression in Nude Mice

December 2014 in “ International Journal of Molecular Medicine ”

Shahnaz Begum, Mi Ra Lee, Li Gu, Jamil Hossain, Chang‐Keun Sung

Eclipta alba hair matrix keratinocytes TGF-β1 petroleum ether extract follicular hypertrophy anagen-phase hair follicles alopecia BrdU-positive cells E. alba PEE hair growth hair follicle regression

TLDR Eclipta alba extract helps increase hair growth and decrease hair loss-related protein in mice.

The study from 2014 examined the effects of Eclipta alba (E. alba) on hair growth in nude mice with genetically distorted hair follicles. The researchers applied a petroleum ether extract (PEE) of E. alba topically to the mice for 20 days and found that it significantly increased the number of hair matrix keratinocytes and decreased the expression of TGF-β1, a protein associated with hair follicle regression. Histological analysis showed follicular hypertrophy and an increase in the number of anagen-phase hair follicles. The study concluded that PEE of E. alba could stimulate hair growth and potentially treat certain types of alopecia. The number of mice in each group was 5, and the number of BrdU-positive cells per anagen follicle in PEE-treated mice was significantly higher (31.2±2) than in control mice (14.9±1.7), indicating increased keratinocyte proliferation.

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