The Extract of Periplaneta Americana Promotes Hair Regrowth in Mice with Alopecia by Regulating the FOXO/PI3K/AKT Signaling Pathway and Skin Microbiota

The study examines the effects of Periplaneta americana extract (PA-011) on hair regrowth in mice with alopecia, involving 44 male C57BL/6J mice. PA-011 significantly enhances hair growth by regulating the FOXO/PI3K/AKT signaling pathway and altering the skin microbiota. The research identifies 1,346 differentially expressed genes and 327 differential metabolites, indicating a dual "antioxidant-anti-inflammatory" mechanism. The extract also promotes hair follicle cell proliferation, increases VEGF expression, and reduces skin micro-inflammation without adverse effects on major organs. These findings suggest PA-011 as a promising candidate for alopecia treatment, though further studies are needed to confirm its efficacy and safety across different alopecia types.