Periplaneta Americana Extract Promotes Hair Regrowth in Alopecia Areata Mice by Reducing Inflammation and Modulating Skin Microbiota

The study on Periplaneta americana extract (PAE) in a mouse model of Alopecia areata (AA) involved 50 female C57BL/6J mice and demonstrated that PAE promotes hair regrowth by reducing inflammation and modulating skin microbiota. PAE treatment improved hair growth rates and skin color scores, and decreased inflammatory markers like TNF-α, IL-23, and VCAM-1. The extract also activated the Wnt signaling pathway, increased hair follicle proliferation, and improved microbial diversity by increasing beneficial probiotics and reducing pathogenic bacteria. These findings suggest PAE's potential as a therapeutic option for AA.