Hair Growth-Promoting Effects of Enz MoriL on Human Dermal Papilla Cells Through Modulation of the Wnt/β-Catenin and JAK-STAT Signaling Pathways

    BoYoon Chang, Jae Hyun Bae, Dong‐Sung Lee, SungYeon Kim
    Image of study
    TLDR Enz_MoriL from mulberry leaves helps hair growth by affecting specific cell pathways.
    Enz_MoriL, derived from Morus alba L. leaves, promotes hair growth by modulating the Wnt/β-Catenin and JAK-STAT signaling pathways in human dermal papilla cells (hDPCs). The study found that Enz_MoriL enhances cell proliferation during both anagen and catagen phases, increases active β-catenin levels, and promotes its nuclear translocation by phosphorylating GSK3β and reducing DKK-1 expression. It also upregulates Wnt family members 3a, 5a, and 7a. Additionally, Enz_MoriL suppresses JAK1 and STAT3 phosphorylation, counteracting the effects of interferon-gamma (IFN-γ) and reversing alopecia areata-like conditions.
    Discuss this study in the Community →

    Research cited in this study

    19 / 19 results

    Related Community Posts Join

    1 / 1 results

      community My boy Saul Goodman was on Minoxidil tabs too

      in Satire  1909 upvotes 4 months ago
      Saul Goodman was humorously depicted using high doses of minoxidil, finasteride, and spironolactone for hair loss. The conversation jokes about the unrealistic dosages and their potential side effects.
      [object Object]

    Similar Research

    5 / 24 results