Hair Growth-Promoting Effects of Enz MoriL on Human Dermal Papilla Cells Through Modulation of the Wnt/β-Catenin and JAK-STAT Signaling Pathways

    BoYoon Chang, Jae Hyun Bae, Dong‐Sung Lee, SungYeon Kim
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    TLDR Enz_MoriL from mulberry leaves helps hair growth by affecting specific cell pathways.
    Enz_MoriL, derived from Morus alba L. leaves, promotes hair growth by modulating the Wnt/β-Catenin and JAK-STAT signaling pathways in human dermal papilla cells (hDPCs). The study found that Enz_MoriL enhances cell proliferation during both anagen and catagen phases, increases active β-catenin levels, and promotes its nuclear translocation by phosphorylating GSK3β and reducing DKK-1 expression. It also upregulates Wnt family members 3a, 5a, and 7a. Additionally, Enz_MoriL suppresses JAK1 and STAT3 phosphorylation, counteracting the effects of interferon-gamma (IFN-γ) and reversing alopecia areata-like conditions.
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