Hair Growth-Promoting Effects of Enz MoriL on Human Dermal Papilla Cells Through Modulation of the Wnt/β-Catenin and JAK-STAT Signaling Pathways
May 2024
in “
Archives of dermatological research
”
Enz_MoriL Morus alba L. Wnt/β-Catenin JAK-STAT human dermal papilla cells hDPCs anagen phase catagen phase β-catenin GSK3β DKK-1 Wnt family members 3a Wnt family members 5a Wnt family members 7a JAK1 STAT3 interferon-gamma IFN-γ alopecia areata white mulberry Wnt signaling JAK-STAT signaling hair growth phase hair loss phase beta-catenin glycogen synthase kinase 3 beta dickkopf-related protein 1 Wnt3a Wnt5a Wnt7a Janus kinase 1 signal transducer and activator of transcription 3 IFN-gamma autoimmune hair loss
TLDR Enz_MoriL from mulberry leaves helps hair growth by affecting specific cell pathways.
Enz_MoriL, derived from Morus alba L. leaves, promotes hair growth by modulating the Wnt/β-Catenin and JAK-STAT signaling pathways in human dermal papilla cells (hDPCs). The study found that Enz_MoriL enhances cell proliferation during both anagen and catagen phases, increases active β-catenin levels, and promotes its nuclear translocation by phosphorylating GSK3β and reducing DKK-1 expression. It also upregulates Wnt family members 3a, 5a, and 7a. Additionally, Enz_MoriL suppresses JAK1 and STAT3 phosphorylation, counteracting the effects of interferon-gamma (IFN-γ) and reversing alopecia areata-like conditions.
