Involvement of DKK1 Secreted From Adipose-Derived Stem Cells in Alopecia Areata

    November 2023 in “ Cell Proliferation ”
    Nahyun Choi, J.-U. Hwang, Doo Yeong Kim, Jino Kim, Seung Yong Song, Jong‐Hyuk Sung
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    TLDR A protein from fat-derived stem cells, DKK1, is linked to hair loss and blocking it may help treat alopecia areata.
    The study investigated the role of DKK1, a protein secreted from adipose-derived stem cells (ASCs), in alopecia areata (AA), a condition causing hair loss. High DKK1 expression was found in AA patients, suggesting a correlation between DKK1 and hair loss. DKK1 was found to hinder hair follicle enlargement and restrict the proliferation of hair follicle stem cells. However, inhibiting DKK1 stimulated hair growth. The researchers created DKK1 knockout ASCs (DKK1-KO-ASCs) which showed increased hair growth-promoting effects and reduced inflammatory responses, making them a promising cell therapy for treating AA. The DKK1 knockout led to the activation of the WNT pathway, promoting hair growth, and the inactivation of the NF-kB pathway, reducing inflammation.
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