Udenafil Induces the Hair Growth Effect of Adipose-Derived Stem Cells

April 2019 in “ Biomolecules & Therapeutics ”

Nahyun Choi, Jong Hwan Sung

Udenafil PDE5 inhibitor adipose-derived stem cells ASCs IL-4 IL12B hair growth therapeutic agent hair loss treatment

TLDR Udenafil may help hair grow by activating certain stem cells.

In 2019, researchers found that Udenafil, a PDE5 inhibitor, could potentially enhance hair growth by stimulating adipose-derived stem cells (ASCs). The study demonstrated that Udenafil increased ASC proliferation, migration, and the secretion of growth factors IL-4 and IL12B, which were found to promote hair growth. When Udenafil-treated ASCs were injected into mice, there was a significant increase in hair growth compared to untreated ASCs. The study concluded that Udenafil could potentially be used as a therapeutic agent for hair loss treatment.

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Research cited in this study

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research IL-17 Inhibition: Is It the Long-Awaited Savior for Alopecia Areata?

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research Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect

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research Hair Growth Promoting Effects of Adipose Tissue-Derived Stem Cells

81 citations, December 2009 in “Journal of Dermatological Science”

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research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

149 citations, April 2004 in “Journal of Dermatological Science”

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research Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

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Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect

research Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect

81 citations, February 1997 in “Journal of Investigative Dermatology”

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research Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture

121 citations, March 1989 in “Journal of Investigative Dermatology”

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research Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action

37 citations, January 1987 in “Dermatology”

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