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GlossaryInterleukin-12 (IL12)

protein that activates immune cells to fight infections

Interleukin-12 (IL-12) is a protein produced by certain immune cells that plays a crucial role in regulating the body's immune response. It helps activate natural killer (NK) cells and T cells, which are essential for fighting infections and cancer. IL-12 is also involved in the inflammatory response and can influence the development of autoimmune diseases.

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research Udenafil Induces the Hair Growth Effect of Adipose-Derived Stem Cells

9 citations, April 2019 in “Biomolecules & Therapeutics”

Udenafil may help hair grow by activating certain stem cells.

Anti-TNF Antibody-Induced Psoriasiform Skin Lesions in Patients with Inflammatory Bowel Disease Are Characterised by Interferon-γ-Expressing Th1 Cells and IL-17A/IL-22-Expressing Th17 Cells and Respond to Anti-IL-12/IL-23 Antibody Treatment

research Anti-TNF Antibody-Induced Psoriasiform Skin Lesions in Patients with Inflammatory Bowel Disease Are Characterised by Interferon-γ-Expressing Th1 Cells and IL-17A/IL-22-Expressing Th17 Cells and Respond to Anti-IL-12/IL-23 Antibody Treatment

278 citations, March 2013 in “Gut”

Anti-IL-12/IL-23 antibody therapy effectively treats psoriasiform skin lesions in IBD patients.

Analysis of Hidradenitis Suppurativa-Linked Mutations in Four Genes and the Effects of PSEN1-P242LfsX11 on Cytokine and Chemokine Expression in Macrophages

research Analysis of Hidradenitis Suppurativa-Linked Mutations in Four Genes and the Effects of PSEN1-P242LfsX11 on Cytokine and Chemokine Expression in Macrophages

25 citations, December 2018 in “Human Molecular Genetics”

The document concludes that certain mutations may contribute to the inflammation in hidradenitis suppurativa and suggests that targeting TNFα could be a treatment strategy.

research Genome-Wide Association Study of Skin Complex Diseases

25 citations, March 2012 in “Journal of Dermatological Science”

Genetic variants linked to ten skin diseases were found, showing both immune and non-immune factors play a role.

research The Genetics of Human Skin Disease

24 citations, October 2014 in “Cold Spring Harbor Perspectives in Medicine”

Genetic research has advanced our understanding of skin diseases, but complex conditions require an integrative approach for deeper insight.

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