Hair Growth Promoting Effects of 15-Hydroxyprostaglandin Dehydrogenase Inhibitor in Human Follicle Dermal Papilla Cells

    NULL AUTHOR_ID, Hak Joong Kim, NULL AUTHOR_ID, Yurim Lee, NULL AUTHOR_ID, Jinsick Kim, Soon Re Kim, Sanghwa Lee, NULL AUTHOR_ID, NULL AUTHOR_ID, NULL AUTHOR_ID, Dong Wook Shin
    TLDR The inhibitor DPP can promote hair growth.
    The study investigated the effects of a 15-hydroxyprostaglandin dehydrogenase inhibitor (DPP) on human follicle dermal papilla cells (HFDPCs) damaged by dihydrotestosterone (DHT). DPP was found to enhance cell viability, promote wound healing, reduce reactive oxygen species (ROS), and restore mitochondrial membrane potential. It also modulated mRNA expression levels of IL-6 and DKK-1 and affected phosphorylation levels of ERK, AKT, GSK-3β, and β-Catenin, activating the AKT/ERK/Wnt signaling pathways. Additionally, DPP increased the size of 3D spheroids and significantly enhanced hair growth in ex vivo human hair follicle organ culture, suggesting its potential as a therapeutic agent for promoting hair growth.
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