Interleukin-6 from Adipose-Derived Stem Cells Promotes Tissue Repair by Increasing Cell Proliferation and Hair Follicles in Ischemia/Reperfusion-Treated Skin Flaps

November 2019 in “ Mediators of inflammation ”

Chi Ming Pu, Ya Chun Chen, Yu Chen Chen, Tzu Lin Lee, Peng Yu, Shun Hua Chen, Yu Hsiu Yen, Chung‐Liang Chien, Jung‐Hsien Hsieh

Interleukin-6 IL-6 adipose-derived stem cells ADSCs cell proliferation hair follicles ischemia/reperfusion skin flaps tissue repair stem cells hair growth skin repair

TLDR IL-6 from stem cells helps repair skin and grow hair.

The study demonstrated that Interleukin-6 (IL-6) secreted by adipose-derived stem cells (ADSCs) significantly promoted tissue repair in ischemia/reperfusion-treated skin flaps by increasing cell proliferation and the formation of new hair follicles. The findings suggested that IL-6 played a crucial role in enhancing the regenerative capabilities of ADSCs, making them a promising therapeutic option for improving skin flap viability and promoting hair growth in damaged tissues.

View this study on hindawi.com →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

research Regeneration of Dermis: Scarring and Cells Involved

176 citations, June 2019 in “Cells”

Different fibroblasts play key roles in skin healing and scarring.

Sericin Hydrogels Promote Skin Wound Healing with Effective Regeneration of Hair Follicles and Sebaceous Glands After Complete Loss of Epidermis and Dermis

research Sericin Hydrogels Promote Skin Wound Healing with Effective Regeneration of Hair Follicles and Sebaceous Glands After Complete Loss of Epidermis and Dermis

84 citations, January 2018 in “Biomaterials Science”

Sericin hydrogels heal skin wounds well, regrowing hair and glands with less scarring.

research Hair Follicle Growth by Stromal Vascular Fraction-Enhanced Adipose Transplantation in Baldness

30 citations, July 2017 in “Stem cells and cloning”

SVF-enhanced adipose transplantation shows potential as a hair loss treatment.

research dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration

128 citations, August 2015 in “Cell Stem Cell”

Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.

research Wound Healing and Skin Regeneration

359 citations, January 2015 in “Cold Spring Harbor Perspectives in Medicine”

Hair growth phase and certain genes can speed up wound healing, while an inflammatory mediator can slow down new hair growth after a wound. Understanding these factors can improve tissue regeneration during wound healing.

Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion

research Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion

134 citations, January 2010 in “Biomedical research”

Low oxygen conditions increase the hair-growing effects of substances from fat-derived stem cells by boosting growth factor release.

Similar Research

5 / 1000+ results

The Combined Use of Platelet-Rich Plasma and Adipose-Derived Mesenchymal Stem Cells Promotes Healing: A Review of Experimental Models and Future Perspectives

research The Combined Use of Platelet-Rich Plasma and Adipose-Derived Mesenchymal Stem Cells Promotes Healing: A Review of Experimental Models and Future Perspectives

4 citations, September 2021 in “Biomolecules”

Using Platelet-Rich Plasma and Adipose-Derived Mesenchymal Stem Cells together can improve healing, including wound healing, bone regeneration, and hair growth.

The Effect of Topical Gel Secretome Hypoxic Mesenchymal Stem Cells on IL-6 and TGF-β Gene Expression in Male Wistar Alopecia-Like Rat Models Induced by Fluconazole

research The Effect of Topical Gel Secretome Hypoxic Mesenchymal Stem Cells on IL-6 and TGF-β Gene Expression in Male Wistar Alopecia-Like Rat Models Induced by Fluconazole

December 2023 in “International journal of multidisciplinary research and analysis”

SH-MSCs gel reduced IL-6 and increased TGF-β, suggesting it could treat alopecia.

research The Role and Prospects of Mesenchymal Stem Cells in Skin Repair and Regeneration

March 2024 in “Biomedicines”

Mesenchymal stem cells show promise for effective skin repair and regeneration.

research Reversing Gray Hair: Inspiring the Development of New Therapies Through Research on Hair Pigmentation and Repigmentation Progress

2 citations, January 2023 in “International journal of biological sciences”

Gray hair can potentially be reversed, leading to new treatments.

research Stem Cell-Derived Exosomes: Emerging Therapeutic Opportunities for Wound Healing

28 citations, April 2023 in “Stem cell research & therapy”

Tiny vesicles from stem cells could be a new treatment for healing wounds.