DKK1-Targeting Cholesterol-Modified siRNA Implication in Hair Growth Regulation

May 2023 in “ Biochemical and Biophysical Research Communications ”

Dimitri Papukashvili, Cong Liu, Nino Rcheulishvili, Fengfei Xie, Xinyun Wang, Shunping Feng, Xiaonan Sun, Chi Zhang, Yingyu Li, Yaohua He, Peng George Wang

DKK1 cholesterol-modified siRNA Wnt/β-catenin signaling pathway androgenetic alopecia small interfering RNA siRNA hair regeneration subcutaneous injections AGA hair growth hair loss

TLDR Blocking DKK1 with siRNA can improve hair growth.

The study "DKK1-targeting cholesterol-modified siRNA implication in hair growth regulation" investigates the role of DKK1, an inhibitor of the Wnt/β-catenin signaling pathway, in hair growth. The researchers found that patients with androgenetic alopecia (AGA) had significantly higher concentrations of DKK1 in their scalp tissue. The study used small interfering RNA (siRNA) technology to target DKK1, with the siRNA sequence validated in vitro and in vivo through subcutaneous injections on mice. The results showed that DKK1-targeting siRNA significantly enhanced hair regeneration compared to the control group, suggesting that inhibiting DKK1 could be a critical factor in promoting hair growth and developing an effective treatment for AGA.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

13 / 13 results

research Perspectives on MicroRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

12 citations, October 2021 in “Cells”

Targeting a protein that blocks hair growth with microRNAs could lead to new hair loss treatments, but more research is needed.

Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia

research Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia

23 citations, January 2021 in “Biomedicine & Pharmacotherapy”

DHT stops hair regrowth in mice, similar to human hair loss.

research Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling

65 citations, July 2020 in “Science Advances”

Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.

research Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

86 citations, July 2020 in “International Journal of Molecular Sciences”

Activating the Wnt/β-catenin pathway could lead to new hair loss treatments.

research Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration

59 citations, March 2020 in “Journal of Biomedical Science”

Understanding how hair follicle stem cells work can help find new ways to prevent hair loss and promote hair growth.

Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations, May 2019 in “Cells”

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

research MiR-218-5p Regulates Skin and Hair Follicle Development Through Wnt/β-Catenin Signaling Pathway by Targeting SFRP2

54 citations, April 2019 in “Journal of cellular physiology”

miR-218-5p helps skin and hair growth by targeting SFRP2 and activating a specific signaling pathway.

research Dickkopf-1 Expression in Androgenetic Alopecia and Alopecia Areata in Male Patients

9 citations, January 2019 in “American Journal of Dermatopathology”

DKK-1 gene linked to hair loss in AGA and AA patients; more research needed for potential therapy.

research Assessment of Tissue Levels of Dickkopf-1 in Androgenetic Alopecia and Alopecia Areata

10 citations, July 2015 in “Journal of Cosmetic Dermatology”

Higher DKK-1 levels found in hair loss patients; L-ascorbic acid 2-phosphate, L-threonate, and ginsenoside F2 may help promote hair growth.

research Modulating Hair Follicle Size with Wnt10b/DKK1 During Hair Regeneration

53 citations, April 2014 in “Experimental Dermatology”

Wnt10b makes hair follicles bigger, but DKK1 can reverse this effect.

Higher Body Mass Index Is Associated With Greater Severity of Alopecia in Men With Male-Pattern Androgenetic Alopecia in Taiwan: A Cross-Sectional Study

research Higher Body Mass Index Is Associated With Greater Severity of Alopecia in Men With Male-Pattern Androgenetic Alopecia in Taiwan: A Cross-Sectional Study

38 citations, November 2013 in “Journal of The American Academy of Dermatology”

Higher BMI links to worse hair loss in Taiwanese men.

research Visible-To-Near IR Quantum Dot-Based Hypermulticolor High-Content Screening of Herbal Medicines for Efficacy Monitoring of Hair Growth Promotion and Hair Loss Inhibition

14 citations, November 2012 in “SLAS discovery”

Some herbal extracts can promote hair growth and prevent hair loss.

research Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes

171 citations, July 2007 in “Journal of Investigative Dermatology”

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.

Similar Research

5 / 556 results

research Perspectives on MicroRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

12 citations, October 2021 in “Cells”

Targeting a protein that blocks hair growth with microRNAs could lead to new hair loss treatments, but more research is needed.

research Hair Growth Promoting Effects of 15-Hydroxyprostaglandin Dehydrogenase Inhibitor in Human Follicle Dermal Papilla Cells

July 2024 in “International Journal of Molecular Sciences”

The inhibitor DPP can promote hair growth.

research Self-Amplifying RNA Approach for Protein Replacement Therapy

8 citations, October 2022 in “International Journal of Molecular Sciences”

Self-amplifying RNA could be a better option for protein replacement therapy with lower doses and lasting effects, but delivering it into cells is still challenging.

Synergistic Phytochemical and Pharmacological Actions of Hair Rise Microemulsion: A Novel Herbal Formulation for Androgenetic Alopecia and Hair Growth Stimulation

research Synergistic Phytochemical and Pharmacological Actions of Hair Rise Microemulsion: A Novel Herbal Formulation for Androgenetic Alopecia and Hair Growth Stimulation

October 2024 in “Plants”

Hair RiseTM microemulsion effectively promotes hair growth and treats hair loss better than standard treatments.

research Wnt/β-Catenin Signaling: Function, Biological Mechanisms, and Therapeutic Opportunities

318 citations, January 2022 in “Signal Transduction and Targeted Therapy”

The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.

DKK1-Targeting Cholesterol-Modified siRNA Implication in Hair Growth Regulation

Research cited in this study

research Perspectives on MicroRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

research Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia

research Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling

research Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

research Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research MiR-218-5p Regulates Skin and Hair Follicle Development Through Wnt/β-Catenin Signaling Pathway by Targeting SFRP2

research Dickkopf-1 Expression in Androgenetic Alopecia and Alopecia Areata in Male Patients

research Assessment of Tissue Levels of Dickkopf-1 in Androgenetic Alopecia and Alopecia Areata

research Modulating Hair Follicle Size with Wnt10b/DKK1 During Hair Regeneration

research Higher Body Mass Index Is Associated With Greater Severity of Alopecia in Men With Male-Pattern Androgenetic Alopecia in Taiwan: A Cross-Sectional Study

research Visible-To-Near IR Quantum Dot-Based Hypermulticolor High-Content Screening of Herbal Medicines for Efficacy Monitoring of Hair Growth Promotion and Hair Loss Inhibition

research Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes

Related Community Posts Join

community Better Than Minoxidil? Topical Sodium Valproate

community Has anyone used Magnesium L-Threonate ?

community VDPHL-01 is Overrated and Ridiculous. This is just Oral Minoxidil.

community Breezula phase 3 results said to be released next month

community DIY treatment... Shedding completely stopped after 1.5 yrs

community The Real Cause Of Androgenetic Alopecia

Similar Research

research Perspectives on MicroRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

research Hair Growth Promoting Effects of 15-Hydroxyprostaglandin Dehydrogenase Inhibitor in Human Follicle Dermal Papilla Cells

research Self-Amplifying RNA Approach for Protein Replacement Therapy

research Synergistic Phytochemical and Pharmacological Actions of Hair Rise Microemulsion: A Novel Herbal Formulation for Androgenetic Alopecia and Hair Growth Stimulation

research Wnt/β-Catenin Signaling: Function, Biological Mechanisms, and Therapeutic Opportunities