DKK1-Targeting Cholesterol-Modified siRNA Implication in Hair Growth Regulation

August 2023 in “ Biochemical and Biophysical Research Communications ”

Dimitri Papukashvili, Cong Liu, Nino Rcheulishvili, Fengfei Xie, Xinyun Wang, Shunping Feng, Xiaonan Sun, Chi Zhang, Yingyu Li, Yaohua He, Peng George Wang

DKK1 cholesterol-modified siRNA Wnt/β-catenin signaling pathway androgenetic alopecia small interfering RNA siRNA hair regeneration subcutaneous injections AGA hair growth hair loss

TLDR Blocking DKK1 with siRNA can improve hair growth.

The study "DKK1-targeting cholesterol-modified siRNA implication in hair growth regulation" investigates the role of DKK1, an inhibitor of the Wnt/β-catenin signaling pathway, in hair growth. The researchers found that patients with androgenetic alopecia (AGA) had significantly higher concentrations of DKK1 in their scalp tissue. The study used small interfering RNA (siRNA) technology to target DKK1, with the siRNA sequence validated in vitro and in vivo through subcutaneous injections on mice. The results showed that DKK1-targeting siRNA significantly enhanced hair regeneration compared to the control group, suggesting that inhibiting DKK1 could be a critical factor in promoting hair growth and developing an effective treatment for AGA.

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