DKK1-Targeting Cholesterol-Modified siRNA Implication in Hair Growth Regulation

May 2023 in “ Biochemical and Biophysical Research Communications ”

Dimitri Papukashvili, Cong Liu, Nino Rcheulishvili, Fengfei Xie, Xinyun Wang, Shunping Feng, Xiaonan Sun, Chi Zhang, Yingyu Li, Yaohua He, Peng George Wang

DKK1 cholesterol-modified siRNA Wnt/β-catenin signaling pathway androgenetic alopecia small interfering RNA siRNA hair regeneration subcutaneous injections AGA hair growth hair loss

TLDR Blocking DKK1 with siRNA can improve hair growth.

The study "DKK1-targeting cholesterol-modified siRNA implication in hair growth regulation" investigates the role of DKK1, an inhibitor of the Wnt/β-catenin signaling pathway, in hair growth. The researchers found that patients with androgenetic alopecia (AGA) had significantly higher concentrations of DKK1 in their scalp tissue. The study used small interfering RNA (siRNA) technology to target DKK1, with the siRNA sequence validated in vitro and in vivo through subcutaneous injections on mice. The results showed that DKK1-targeting siRNA significantly enhanced hair regeneration compared to the control group, suggesting that inhibiting DKK1 could be a critical factor in promoting hair growth and developing an effective treatment for AGA.

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Research cited in this study

research Perspectives on MicroRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

research Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia

research Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling

research Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

research Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research MiR-218-5p Regulates Skin and Hair Follicle Development Through Wnt/β-Catenin Signaling Pathway by Targeting SFRP2

research Dickkopf-1 Expression in Androgenetic Alopecia and Alopecia Areata in Male Patients

research Assessment of Tissue Levels of Dickkopf-1 in Androgenetic Alopecia and Alopecia Areata

research Modulating Hair Follicle Size with Wnt10b/DKK1 During Hair Regeneration

research Higher Body Mass Index Is Associated With Greater Severity of Alopecia in Men With Male-Pattern Androgenetic Alopecia in Taiwan: A Cross-Sectional Study

research Visible-To-Near IR Quantum Dot-Based Hypermulticolor High-Content Screening of Herbal Medicines for Efficacy Monitoring of Hair Growth Promotion and Hair Loss Inhibition

research Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes

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