Androgen Responsive Genes as They Affect Hair Growth

August 2001 in “ PubMed ”

Marty E. Sawaya, Robert W. Keane, Ulrike Blume‐Peytavi, Diane Mullins, Bernard P. Nusbaum, David Whiting, Donald W. Nicholson

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androgenetic alopecia caspases caspase 3 finasteride dihydrotestosterone apoptosis hair follicles programmed cell death hair growth cycle AGA Propecia DHT

Studysummary In this study, finasteride treatment in men with androgenetic alopecia reduced the expression of caspases in hair follicles to levels similar to those in men with normal scalps.

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The study investigated the effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia. Finasteride, a medication known to inhibit the conversion of testosterone to dihydrotestosterone (DHT), was shown to reduce scalp and serum DHT levels, which are implicated in hair loss. The study concluded that finasteride effectively lowered DHT levels, thereby potentially mitigating hair loss in men with androgenetic alopecia. The research involved a clinical trial, but the document did not specify the number of participants involved.

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