Flavonoid Silibinin Increases Hair-Inductive Property Via Akt and Wnt/β-Catenin Signaling Activation in 3-Dimensional Spheroid Cultured Human Dermal Papilla Cells

The study investigated the effects of silibinin, a flavonoid, on hair-inductive properties in human dermal papilla cells cultured in a 3D spheroid model. Silibinin was found to enhance cell viability and increase the size of DP spheroids by activating the Akt and Wnt/β-catenin signaling pathways. This activation led to increased expression of hair-inductive genes such as WNT5a and LEF1. The findings suggested that silibinin could be a potential therapeutic candidate for promoting hair growth and treating hair loss, offering a promising alternative to existing treatments like minoxidil and finasteride. Further studies were recommended to fully understand its clinical efficacy.