New Plant Extracts Exert Complementary Anti-Hair Loss Properties in Human In Vitro and Ex Vivo Models

    November 2024 in “ Journal of Cosmetic Dermatology
    Daniel Bacqueville, Marguerite Lévêque, Camille Mas, Marie‐José Haure, Anaïs Noustens, V. Mengeaud, Sophie Carrère, S. Bessou‐Touya, Jimmy Le Digabel, Nicoletta Rizzi, Jean‐Hilaire Saurat
    Image of study
    TLDR The plant extracts may help treat hair loss by promoting hair growth and reducing DHT levels.
    The study explored the effects of three natural extracts—Silybum marianum extract (SME), Lespedeza capitata extract (LCE), and manganese salt of L-pyrrolidone carboxylic acid (MnPCA)—on hair growth using human in vitro and ex vivo models. SME was found to stimulate hair growth through EGFR/PDGFR pathways, while MnPCA activated the Wnt/β-catenin pathway, enhancing versican and VEGF production. LCE reduced DHT levels and inhibited androgen metabolism. A serum containing these extracts improved hair growth and prolonged the anagen phase in ex vivo models, suggesting potential benefits for treating hair loss. However, the study noted limitations such as a small number of donors and lack of vascularization in the ex vivo model, indicating the need for further clinical studies.
    Discuss this study in the Community →

    Research cited in this study

    33 / 33 results

    Related Community Posts Join

    3 / 3 results
      [object Object]

      community Melatonin emerging as new treatment for androgenic alopecia?

      in Update  36 upvotes 1 month ago
      Melatonin is being considered as a potential treatment for androgenic alopecia, with some users discussing its effects and combining it with other treatments like minoxidil and finasteride. Concerns about melatonin's impact on hormones and side effects from other treatments like ketoconazole were also discussed.

    Related Research

    4 / 4 results