A New Combination of Molecules for the Treatment of Androgenetic Alopecia and Telogen Effluvium: A Double-Blind Randomized, Monocentric, Placebo-Controlled Study

    January 2022 in “ Italian journal of dermatology and venereology ”
    Alfredo De Rossi, Francesca Magri, Marco Di Fraia, Gemma Caro, Maria Caterina Fortuna, Marco Piacentini, Leonardo Celleno
    TLDR The combination of arginine and zinc reduces hair loss and increases hair growth effectively.
    The study investigated the efficacy of a topical treatment containing a combination of arginine and zinc for androgenetic alopecia (AGA) and telogen effluvium (TE). In-vitro tests demonstrated that this combination significantly inhibited the 5α-reductase enzyme in dermal papillae cells. The in-vivo study involved 40 participants with AGA and TE, divided into two groups, with one receiving the treatment and the other a placebo over 23 weeks. Results showed a significant reduction in hair loss and an increase in anagen hair in the treatment group. Phototrichograms confirmed better outcomes for the treatment group compared to the placebo. The study concludes that this combination could be a promising alternative to finasteride for treating AGA and TE.
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