A New Combination of Molecules for the Treatment of Androgenetic Alopecia and Telogen Effluvium: A Double-Blind Randomized, Monocentric, Placebo-Controlled Study

January 2022 in “ Italian journal of dermatology and venereology ”

Alfredo De Rossi, Francesca Magri, Marco Di Fraia, Gemma Caro, Maria Caterina Fortuna, Marco Piacentini, Leonardo Celleno

androgenetic alopecia telogen effluvium arginine zinc 5α-reductase dermal papillae cells anagen hair phototrichograms finasteride AGA TE 5-alpha-reductase hair growth phase hair loss treatment

TLDR The combination of arginine and zinc reduces hair loss and increases hair growth effectively.

The study investigated the efficacy of a topical treatment containing a combination of arginine and zinc for androgenetic alopecia (AGA) and telogen effluvium (TE). In-vitro tests demonstrated that this combination significantly inhibited the 5α-reductase enzyme in dermal papillae cells. The in-vivo study involved 40 participants with AGA and TE, divided into two groups, with one receiving the treatment and the other a placebo over 23 weeks. Results showed a significant reduction in hair loss and an increase in anagen hair in the treatment group. Phototrichograms confirmed better outcomes for the treatment group compared to the placebo. The study concludes that this combination could be a promising alternative to finasteride for treating AGA and TE.

View this study on minervamedica.it →

Discuss this study in the Community →

Research cited in this study

9 / 9 results

research Efficacy of Topical Finasteride 0.5% vs 17α-Estradiol 0.05% in the Treatment of Postmenopausal Female Pattern Hair Loss: A Retrospective, Single-Blind Study of 119 Patients

4 citations, April 2020 in “Dermatology practical & conceptual”

Topical finasteride works faster and better than 17α-estradiol for postmenopausal hair loss.

Treatment of Telogen Effluvium Using a Dietary Supplement Containing Boswellia Serrata, Curcuma Longa, and Vitis Vinifera: Results of an Observational Study

research Treatment of Telogen Effluvium Using a Dietary Supplement Containing Boswellia Serrata, Curcuma Longa, and Vitis Vinifera: Results of an Observational Study

37 citations, January 2019 in “Dermatologic Therapy”

A dietary supplement with Boswellia serrata, Curcuma longa, and Vitis vinifera showed potential improvement in hair health for telogen effluvium patients, but more research is needed.

research The Role of Vitamins and Minerals in Hair Loss: A Review

134 citations, December 2018 in “Dermatology and Therapy”

Some vitamins and minerals like vitamin D and iron can help with certain types of hair loss, but more research is needed for others.

research Potential Applications of Topical Oxygen Therapy in Dermatology

7 citations, October 2018 in “Dermatology practical & conceptual”

Topical oxygen therapy may improve treatments for hair loss, acne, and chronic skin diseases with minimal side effects.

research Estimation of Zinc and Iron Levels in the Serum and Hair of Women with Androgenetic Alopecia: Case-Control Study

15 citations, January 2018 in “Indian Journal of Dermatology”

Women with androgenetic alopecia have lower zinc and iron levels.

Histological Evaluation of Follicular Delivery of Arginine via Nanostructured Lipid Carriers: A Novel Potential Approach for the Treatment of Alopecia

research Histological Evaluation of Follicular Delivery of Arginine via Nanostructured Lipid Carriers: A Novel Potential Approach for the Treatment of Alopecia

17 citations, October 2016 in “Artificial Cells Nanomedicine and Biotechnology”

Using tiny fat particles to deliver arginine to hair follicles could be a new way to treat hair loss.

research Evaluation of Efficacy and Safety of Finasteride 1 mg in 3177 Japanese Men with Androgenetic Alopecia

41 citations, October 2011 in “Journal of Dermatology”

Finasteride 1 mg effectively and safely increases hair growth in Japanese men with hair loss.

research Finasteride, 1 Mg Daily Administration on Male Androgenetic Alopecia in Different Age Groups: 10-Year Follow-Up

44 citations, July 2011 in “Dermatologic Therapy”

Finasteride effectively increases hair growth in men with AGA, works better for those over 30, and may cause some side effects.

research Female Pattern Hair Loss in Complete Androgen Insensitivity Syndrome

54 citations, February 2010 in “British Journal of Dermatology”

Hair loss in women may have causes other than hormones.

Similar Research

5 / 1000+ results

research Clinical And Preclinical Approach In AGA Treatment: A Review Of Current And New Therapies In The Regenerative Field

August 2024 in “Stem Cell Research & Therapy”

New regenerative therapies show promise for treating hair loss.

research Alternative Medicine for Hair Loss

1 citations, May 2017 in “InTech eBooks”

Some natural remedies may help with hair regrowth, but more research is needed to confirm their effectiveness and safety.

research Safety and Efficacy of Hair Growth Promoting Product in Adult Human Subjects With Alopecia

December 2023 in “Journal of Cosmetic Dermatology”

The hair growth product was effective and safe, increasing hair growth, thickness, and density while reducing hair fall.

research The Role of Dietary Supplements in Hair Loss Treatment: A Review of Evidence

2 citations, July 2018 in “Elsevier eBooks”

Some supplements may help with hair loss, but there's not enough strong evidence to recommend them without doctor advice.

research Proceedings of the Ninth World Congress for Hair Research 2015

January 2017 in “Journal of Investigative Dermatology Symposium Proceedings”

The 2015 Hair Research Congress concluded that stem cells, maraviroc, and simvastatin could potentially treat Alopecia Areata, topical minoxidil, finasteride, and steroids could treat Frontal Fibrosing Alopecia, and PTGDR2 antagonists could also treat alopecia. They also found that low-level light therapy could help with hair loss, a robotic device could assist in hair extraction, and nutrition could aid hair growth. They suggested that Alopecia Areata is an inflammatory disorder, not a single disease, indicating a need for personalized treatments.