P122: Flavonoid Silibinin Induces Hair Growth in 3-Dimensional Cultured Human Dermal Papilla Cells
January 2019
in “
프로그램북(구 초록집)
”
TLDR Silibinin may help hair growth and treat hair loss.
The study investigated the effects of silibinin, a compound from Silybum marianum, on hair growth using 3D-cultured human dermal papilla cells. It was found that silibinin significantly increased cell viability and activated the Akt and Wnt/β-catenin signaling pathways. This activation led to increased expression of genes associated with hair growth, such as WNT5a, LEF1, ALPL, VCAN, FGF7, and BMP2. The results suggested that silibinin could be a potential therapeutic option for treating alopecia by promoting hair growth through these pathways.
