Bacillus/Trapa Japonica Fruit Extract Ferment Filtrate Enhances Human Hair Follicle Dermal Papilla Cell Proliferation via the Akt/ERK/GSK-3β Signaling Pathway

May 2019 in “ BMC Complementary and Alternative Medicine ”

Gun-He Nam, Kyung-Jo Jo, Ye-Seul Park, Hye Won Kawk, Je-Geun Yoo, Jin Jang, Sang Moon Kang, Sang-Yong Kim, Young-Min Kim

Bacillus/Trapa japonica fruit extract ferment filtrate human hair follicle dermal papilla cells Akt signaling pathway ERK signaling pathway GSK-3β signaling pathway hair growth factors cell cycle progression apoptosis angiogenesis type I 5α-reductase alopecia TJFs HDP cells hair loss hair growth

TLDR The extract from Bacillus/Trapa japonica fruit helps increase hair growth and could be a potential treatment for hair loss.

In the 2019 study, Bacillus/Trapa japonica fruit extract ferment filtrate (TJFs) was found to stimulate human hair follicle dermal papilla (HDP) cell proliferation and migration via the Akt/ERK/GSK-3β signaling pathway. The treatment with TJFs led to increased expression of hair growth factors, progression of the cell cycle, reduced apoptosis, enhanced angiogenesis, and decreased activity of type I 5α-reductase, which is associated with hair loss. The study's assays and models confirmed these effects, suggesting TJFs could be a promising treatment for alopecia. The number of participants or cells used in the study was not specified in the provided text.

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