The Role of Prostaglandins in Androgenetic Alopecia

February 2021 in “ International Journal of Dermatology ”

E. Chovarda, Elena Sotiriou, Elizabeth Lazaridou, Efstratios Vakirlis, D. Ioannides

prostaglandins PGD2 PGE2 androgenetic alopecia prostaglandin receptors AGA

TLDR Prostaglandins may contribute to male hair loss; targeting them could help treat it.

Prostaglandins, specifically PGD2 and PGE2, may play a role in the development of androgenetic alopecia (AGA) in males, as they were found to be higher in balding areas of male participants with AGA but not in female participants with AGA. Targeting prostaglandin receptors could be a potential treatment for AGA. Further research is needed to fully understand the role of prostaglandins in hair loss and develop effective treatments.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Cited in this study

20 / 20 results

research Minoxidil And Its Use In Hair Disorders: A Review

117 citations , August 2019 in “Drug Design Development and Therapy”

Minoxidil effectively treats hair loss, but use cautiously and monitor side effects.

research Female Pattern Hair Loss: A Clinical, Pathophysiologic, and Therapeutic Review

66 citations , December 2018 in “International Journal of Women's Dermatology”

No cure for female pattern hair loss, but various effective treatments exist.

research Prostanoids and Hair Follicles: Implications for Therapy of Hair Disorders

16 citations , January 2018 in “Acta dermato-venereologica”

Prostanoids, like prostaglandins and thromboxane A2, can both enhance and inhibit hair growth, and understanding their effects could help treat hair disorders.

research Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes

9 citations , October 2017 in “Journal of Investigative Dermatology Symposium Proceedings”

Prostaglandin D2 increases testosterone production in skin cells through a process involving reactive oxygen species, and antioxidants may help treat hair loss.

research The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis

178 citations , July 2017 in “Journal of The American Academy of Dermatology”

Minoxidil, finasteride, and low-level laser light therapy effectively treat hair loss.

research Classification of Male-Pattern Hair Loss

9 citations , July 2017 in “International Journal of Trichology”

No current system perfectly classifies male-pattern hair loss, indicating a need for a new system for better diagnosis and treatment.

research Genetics and Other Factors in the Etiology of Female Pattern Hair Loss

43 citations , June 2017 in “Experimental Dermatology”

Female pattern hair loss has unclear causes, possibly involving genetics, hormones, and environment, and needs better treatments.

research Multi-Therapies in Androgenetic Alopecia: Review and Clinical Experiences

55 citations , July 2016 in “Dermatologic Therapy”

Multiple treatments work best for hair loss.

research An Observational Study of the Association Between Androgenetic Alopecia and Size of the Prostate

6 citations , April 2016 in “International Journal of Trichology”

The conclusion is that more hair loss (androgenetic alopecia) is linked to larger prostate size, suggesting hair loss could be an early sign of benign prostatic hyperplasia.

research Classifications of Patterned Hair Loss: A Review

101 citations , January 2016 in “Journal of Cutaneous and Aesthetic Surgery”

Different types of hair loss need specific treatments, and while many classification systems exist, each has its flaws; more research is needed to refine these systems and treatments.

research Female Pattern Hair Loss: An Overview

14 citations , February 2015 in “Current problems in dermatology”

Female pattern hair loss treatments vary in effectiveness and may have side effects.

research Does Prostaglandin D2 Hold the Cure to Male Pattern Baldness?

57 citations , March 2014 in “Experimental Dermatology”

Prostaglandin D₂ might be targeted for new male pattern baldness treatments.

research The Prostamide-Related Glaucoma Therapy, Bimatoprost, Offers a Novel Approach for Treating Scalp Alopecias

53 citations , October 2012 in “The FASEB Journal”

Bimatoprost, a glaucoma medication, may also help treat hair loss.

research Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

205 citations , March 2012 in “Science Translational Medicine”

PGD2 stops hair growth and is higher in bald men with AGA.

research Hair Loss in Women: Medical and Cosmetic Approaches to Increase Scalp Hair Fullness

75 citations , December 2011 in “British Journal of Dermatology”

Female pattern hair loss can be treated with medications, surgery, and cosmetic products, considering its psychological impact.

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men

198 citations , October 2011 in “Journal der Deutschen Dermatologischen Gesellschaft”

Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.

research Prostanoid Receptors in Anagen Human Hair Follicles

39 citations , November 2007 in “Experimental dermatology”

Human hair follicles contain a complex network of prostanoid receptors that may influence hair growth.

research Prostaglandin Metabolism in Human Hair Follicle

65 citations , August 2007 in “Experimental Dermatology”

Human hair follicles can make and process prostaglandins, which may affect hair growth.

research Influence of Prostaglandin F2α and Its Analogues on Hair Regrowth and Follicular Melanogenesis in a Murine Model

103 citations , April 2005 in “Experimental dermatology”

Prostaglandin F2alpha and related compounds can increase hair growth and darken hair in mice.

research Minoxidil: Mechanisms of Action on Hair Growth

397 citations , February 2004 in “British Journal of Dermatology”

Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.

6 / 6 results

research Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil

1 citations , November 2022 in “JAAD case reports”

Tofacitinib and oral minoxidil may help treat Sisaipho alopecia areata.

research The Role of Prostaglandins in Androgenetic Alopecia

4 citations , February 2021 in “International Journal of Dermatology”

Prostaglandins may contribute to male hair loss; targeting them could help treat it.

research Hair Disorders

August 2018 in “Oxford University Press eBooks”

The document's conclusion cannot be provided because the document cannot be parsed.

research Hair Loss (Alopecia or Baldness)

June 2018

Baldness is often hereditary and linked to male hormones, becoming noticeable when half the hair is lost.

research Treatments of Hereditary Hair Loss (Alopecia)

April 2018

Some treatments like minoxidil, finasteride, and surgery can help with hereditary hair loss.

research Disorders of Hair

July 2013 in “DeckerMed Medicine”

The document's conclusion cannot be provided because the document is not readable or understandable.