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    Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes

    September 2017 in “ Journal of Investigative Dermatology Symposium Proceedings ”
    Alon Mantel, J. Tyson McDonald, Kennedy Goldsborough … Joel Chan
    Studysummary In this study, PGD2 was shown to increase testosterone production in human keratinocytes through reactive oxygen species, suggesting potential benefits of antioxidants like N-acetyl-cysteine for AGA patients.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 8

    1. 15-Deoxy Prostaglandin J2, The Nonenzymatic Metabolite Of Prostaglandin D2, Induces Apoptosis In Keratinocytes Of Human Hair Follicles: A Possible Explanation For Prostaglandin D2-Mediated Inhibition Of Hair Growth Naunyn-Schmiedeberg's Archives of Pharmacology · 2016
    2. Sulforaphane Promotes Murine Hair Growth by Accelerating the Degradation of Dihydrotestosterone Biochemical and Biophysical Research Communications · 2016
    3. Oxidative Stress in Alopecia Areata: A Case-Control Study American Journal of Clinical Dermatology · 2013
    4. Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis Through the Receptor Gpr44 Journal of Investigative Dermatology · 2012
    5. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012
    6. Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men Journal der Deutschen Dermatologischen Gesellschaft · 2011
    7. Hormonal Basis of Male and Female Androgenic Alopecia: Clinical Relevance Skin Pharmacology and Physiology · 2009
    8. Influence of Prostaglandin F2α and Its Analogues on Hair Regrowth and Follicular Melanogenesis in a Murine Model Experimental dermatology · 2005