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    Sulforaphane Promotes Murine Hair Growth by Accelerating the Degradation of Dihydrotestosterone

    February 2016 in “ Biochemical and Biophysical Research Communications ”
    Mari Sasaki, Shohei Shinozaki, Kentaro Shimokado
    Studysummary This study found that sulforaphane treatment enhanced hair regeneration in ob/ob mice by increasing DHT-degrading enzyme levels and lowering plasma testosterone and DHT.
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    Research cited in this study 13

    1. Telogen Elongation in the Hair Cycle of ob/ob Mice Bioscience, Biotechnology, and Biochemistry · 2015
    2. Leptin of Dermal Adipose Tissue Is Differentially Expressed During the Hair Cycle and Contributes to Adipocyte-Mediated Growth Inhibition of Anagen-Phase Vibrissa Hair Experimental Dermatology · 2014
    3. Androgenetic Alopecia: An Evidence-Based Treatment Update American Journal of Clinical Dermatology · 2014
    4. Hair Cycle Control by Leptin as a New Anagen Inducer Experimental Dermatology · 2013
    5. HSL Attenuates Follicular Oxidative Stress and Enhances Hair Growth in ob/ob Mice Plastic and Reconstructive Surgery – Global Open · 2013
    6. The Efficacy and Safety of 5α-Reductase Inhibitors in Androgenetic Alopecia: A Network Meta-Analysis and Benefit–Risk Assessment of Finasteride and Dutasteride Journal of Dermatological Treatment · 2013
    7. Quality of Life Assessment in Male Patients with Androgenetic Alopecia: Results of a Prospective, Multicenter Study Annals of Dermatology · 2012
    8. Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia American Journal of Pathology · 2007
    9. The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride Journal of The American Academy of Dermatology · 2006
    10. Steroidogenic Isoenzymes in Human Hair and Their Potential Role in Androgenetic Alopecia Dermatology · 2003
    11. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
    12. A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-Alpha-Reductase in the Treatment of Androgenetic Alopecia Journal of Alternative and Complementary Medicine · 2002
    13. The Psychosocial Consequences of Androgenetic Alopecia: A Review of the Research Literature British Journal of Dermatology · 1999

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    1. Age-Dependent Regulation by Androgens of Gene Expression in the Anterior Hypothalamus and Stress-Induced Release of Adrenal Hormones in Adolescent and Adult Male Rats Journal of neuroendocrinology · 2019