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Did you mean Prostaglandin D2 Receptor?

Glossary Prostaglandin D2 Receptor

protein on cell surfaces that binds prostaglandin D2, affecting hair growth

The Prostaglandin D2 Receptor (often abbreviated as PTGDR or PTGDR2) is a protein found on the surface of certain cells that binds to prostaglandin D2, a type of lipid compound involved in various physiological processes. This receptor plays a significant role in inflammatory responses and has been linked to conditions like asthma and hair loss, particularly androgenetic alopecia, where its activation can inhibit hair growth.

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Research

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research Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis through the Receptor, Gpr44

68 citations , November 2012 in “Journal of Investigative Dermatology”

This study found that PGD2 inhibits hair follicle regeneration in mice through the Gpr44 receptor, suggesting that blocking PGD2 or Gpr44 may enhance skin regeneration after wounds.

research Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells

18 citations , February 2018 in “International Journal of Molecular Sciences”

This study found that prostaglandin D2 promotes androgen receptor and AKT signaling in human dermal papilla cells through the DP2 receptor, potentially contributing to androgenetic alopecia.

research Human Scalp Hair Follicles Express Prostaglandin E2 Lipid Mediator and Receptors For Pge2

September 2013

This study found that isolated human scalp hair follicles express PGE2 genes and EP2 protein, suggesting PGE2 may play a crucial role in regulating hair growth.

Topical Latanoprost Acid for Female Androgenetic Alopecia: A Pilot Proof-Of-Concept Trial With Mechanistic Evidence of Prostaglandin F2α Receptor Activation

research Topical latanoprost acid for female androgenetic alopecia: a pilot proof-of-concept trial with mechanistic evidence of prostaglandin F2α receptor activation

July 2026 in “Pharmacological Reports”

In this pilot study, topical latanoprost acid was observed to increase hair count and improve hair follicle structure in women with androgenetic alopecia, with no serious adverse events, suggesting potential for further investigation to confirm its efficacy and safety.

research Expression Level of Prostaglandin D2 Receptor 2 Regulates Hair Regression

2 citations , February 2019 in “Journal of Investigative Dermatology”

This study suggests that the expression of the DP2 receptor is higher in balding scalp cells and that its knockdown could inhibit the transition to the catagen phase in cultured human hair follicles, potentially counteracting hair growth inhibition associated with male pattern baldness.

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community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

3 upvotes 1 year ago

DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.

community You will lose hair if your prostaglandins aren't in balance

56 upvotes 1 year ago

Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

community Chromosome 20’s balding effects and why fin likely isn’t working for some.

in Treatment 96 upvotes 1 year ago

Finasteride is effective for DHT/AR-driven hair loss but not for chromosome 20-driven cases, where treatments like minoxidil, prostaglandin analogs, and low-level laser therapy may be more beneficial. Genetic testing can help determine the underlying cause of hair loss to tailor treatment effectively.

community Doubts about castor oil

5 upvotes 7 years ago

Castor oil's effectiveness for hair growth is debated, with concerns about its impact on skin health and prostaglandin levels. Some users suggest combining it with coconut oil and using it alongside finasteride for better results, while others recommend sticking to proven synthetic treatments.

community Hey med experts explain this please??

7 upvotes 1 year ago

Finasteride, dutasteride, saw palmetto, caffeine, spironolactone, acetyltetrapeptides, tea tree oil, hydrocortisone, zinc pyrithione, latanoprost, melatonin, marine protein supplements, PRP, microneedling, and valproate are discussed as treatments for hair loss. DHT reduction and inflammation control are key strategies.

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Learn

2 / 801 results

learn Setipiprant

What is Setipiprant and how does it differ from DHT blockers like finasteride or dutasteride? Setipiprant blocks the prostaglandin D2 receptor DP2 rather than the DHT pathway that finasteride and dutasteride act on. The one published human trial — a 169-man, 24-week phase 2a study at 2,000 mg a day — reported no statistically significant improvement in hair density over placebo, and setipiprant is not an approved hair-loss medicine anywhere.
How does Setipiprant work on the scalp to potentially promote hair regrowth? Setipiprant blocks the DP2 (CRTH2) receptor that prostaglandin D₂ acts through, and PGD₂ is reported to be elevated in balding scalp — but the one published placebo-controlled trial in men (DuBois 2021, n=169) found no significant hair regrowth. It is an experimental compound, not an approved hair-loss medicine.

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