Microneedle-Mediated Delivery of Immunomodulators Restores Immune Privilege in Hair Follicles and Reverses Immune-Mediated Alopecia

    April 2024 in “ Advanced Materials ”
    Nour K. Younis, Núria Puigmal, Abdullah El-Kurdi, Andrew Badaoui, Dongliang Zhang, Claudia Morales‐Garay, Anis J. Saad, Diane Cruz, Nadim Al Rahy, Andrea Daccache, Triana Huerta, Christa Deban, Ahmad Halawi, John Y. Choi, Pere Dosta, Christine G. Lian, Natalie Artzi, Jamil Azzi
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    TLDR A microneedle patch can help regrow hair by restoring immune balance in hair follicles.
    The study investigates a novel approach to treating alopecia areata, an autoimmune condition causing localized hair loss, by using a hydrogel microneedle (MN) patch to deliver CCL22 and IL-2, which attract and support regulatory T cells (Tregs) at the site of hair follicles. This method aims to restore immune balance locally without systemic immunosuppression. In a murine model, the treatment led to sustained hair regrowth and reduced inflammation. Additionally, in a humanized skin transplant mouse model, Treg expansion was confirmed in human skin without peripheral immunosuppression. The MN patch demonstrated high-loading capacity and stability, indicating potential for clinical application.
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      community microneedle, any long term users damage?

      in Microneedling  35 upvotes 6 months ago
      Microneedling is effective for hair growth, especially when combined with finasteride and minoxidil, but concerns exist about potential long-term skin damage. Users report increased collagen and elastin deposition, but the long-term effects on the scalp remain uncertain.

      community Microneedle and aloe vera after?

      in Microneedling  5 upvotes 2 years ago
      The user plans to use a 1.5 mm dermapen for microneedling every 10 days and is considering applying aloe vera afterward. They also inquire about the timing for washing their hair before and after the treatment.

      community Best Microneedle Lengths To Stimulate Stem Cells

      in Microneedling  18 upvotes 1 year ago
      Microneedling with needle lengths of 1.5mm to 2.5mm to stimulate hair follicle stem cells for potential hair growth. Using needles longer than 2.5mm is not recommended due to risk of puncturing veins in the scalp. A dermastamp is suggested over a roller.

      community How often to microneedle for optimal results

      in Microneedling  10 upvotes 2 months ago
      Microneedling for hair loss is discussed, with users suggesting different frequencies and needle lengths, such as 1.5mm every 3 to 6 weeks or 1.0mm weekly. Some users recommend less frequent sessions to avoid scalp damage and soreness.

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