Microneedle-Mediated Delivery of Immunomodulators Restores Immune Privilege in Hair Follicles and Reverses Immune-Mediated Alopecia

    April 2024 in “ Advanced Materials ”
    Nour K. Younis, Núria Puigmal, Abdullah El-Kurdi … Jamil Azzi
    Studysummary This study tested a hydrogel microneedle patch delivering T reg attractants in mice with alopecia, finding it boosted regulatory T cell numbers at the site, leading to hair regrowth without causing peripheral immunosuppression, suggesting a potential new approach for autoimmune skin disease treatment.
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    Research cited in this study 15

    1. Regulatory T Cells in Skin Mediate Immune Privilege of the Hair Follicle Stem Cell Niche Science Immunology · 2024
    2. Trends in Prevalence and Incidence of Alopecia Areata, Alopecia Totalis, and Alopecia Universalis Among Adults and Children in a US Employer-Sponsored Insured Population JAMA Dermatology · 2023
    3. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    4. Regulatory T Cells: The Many Faces of Foxp3 Journal of Clinical Immunology · 2019
    5. Combination of Photodynamic Therapy with 5-Aminolaevulinic Acid and Microneedling in the Treatment of Alopecia Areata Resistant to Conventional Therapies: Our Experience with 41 Patients Clinical and Experimental Dermatology · 2019
    6. Regulatory T Cells in Inflammatory Skin Disease: From Mice to Humans International immunology · 2019
    7. Regulatory T Cells in Autoimmune Skin Diseases Experimental Dermatology · 2018
    8. Randomized Trial of Electrodynamic Microneedle Combined with 5% Minoxidil Topical Solution for the Treatment of Chinese Male Androgenetic Alopecia Journal of Cosmetic and Laser Therapy · 2017
    9. Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model Annals of Dermatology · 2016
    10. Topical Products for Human Hair Regeneration: A Comparative Study on an Animal Model Annals of Dermatology · 2016
    11. Response to Microneedling Treatment in Men with Androgenetic Alopecia Who Failed to Respond to Conventional Therapy Indian Journal of Dermatology · 2015
    12. Red Ginseng Extract Promotes Hair Growth in Cultured Human Hair Follicles Journal of Medicinal Food · 2014
    13. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    14. Alopecia Areata: Successful Outcome with Microneedling and Triamcinolone Acetonide Journal of Cutaneous and Aesthetic Surgery · 2014
    15. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012

    Related research 3

    1. Understanding Immune Privilege in an Inducible Mouse Model of Primary Cicatricial Alopecia ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2023
    2. The Immunopathobiology of Lichen Planopilaris [Thesis]. Manchester, UK: The University of Manchester; 2011. · 2011
    3. Does Collapse of Immune Privilege in the Hair-Follicle Bulge Play a Role in the Pathogenesis of Primary Cicatricial Alopecia? Clinical and Experimental Dermatology · 2009