Pilose Antler Extract Promotes Hair Growth in Androgenic Alopecia Mice by Promoting the Initial Anagen Phase

April 2024 in “ Biomedicine & pharmacotherapy ”

Menghua Liu, Gaiying He, Fenglong Wang, Yanan Sun, Shanshan Ma, Hui Yu, Xun Hu

Pilose Antler Extract androgenic alopecia anagen phase telogen phase hair follicle stem cells matrix cells Sonic Hedgehog signaling pathway BMP/Smad pathway PAE AGA SHH signaling pathway

TLDR Pilose antler extract helps hair grow in mice with a type of hair loss by speeding up the growth phase.

The study examined the impact of Pilose Antler Extract (PAE) on hair growth in mice with androgenic alopecia (AGA). The results showed that PAE significantly promoted hair growth by accelerating the transition from the telogen (resting) phase to the anagen (growth) phase. This was achieved by enhancing the proliferation of hair follicle stem cells and matrix cells. Additionally, PAE increased the expression of the Sonic Hedgehog (SHH) signaling pathway, which is crucial for hair growth, and suppressed the BMP/Smad pathway. The study concluded that PAE could potentially be used to improve hair regeneration in AGA.

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