Pilose Antler Extracts Promote Hair Growth in Androgenetic Alopecia Mice by Activating Hair Follicle Stem Cells via the AKT and Wnt Pathways

    July 2024 in “ Frontiers in Pharmacology
    Fenglong Wang, Gaiying He, Menghua Liu, Yanan Sun, Shuhua Ma, Zhenxiao Sun, Yi Wang
    TLDR Pilose antler extracts help hair growth by activating hair follicle stem cells.
    The study investigated the effects of pilose antler extracts (PAEs) on hair growth in androgenetic alopecia (AGA) mice, focusing on hair follicle stem cells (HFSC). PAEs were found to promote hair regrowth by accelerating the activation of the anagen phase, delaying the anagen-catagen transition, and alleviating hair thinning and miniaturization. The extracts enhanced the proliferation of HFSC, outer root sheath cells, and hair bulb cells. Mechanistically, PAEs activated the PI3K-AKT and Wnt-β-Catenin pathways, which are crucial for HFSC proliferation. Blocking these pathways inhibited HFSC proliferation, confirming their role in PAEs' hair growth-promoting effects.
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