Pyridoxine Regulates Hair Follicle Development via the PI3K/Akt, Wnt, and Notch Signalling Pathways in Rex Rabbits

A study conducted on 200 rex rabbits found that pyridoxine, also known as vitamin B6, significantly increased hair follicle density and promoted hair growth. The rabbits were divided into 5 groups and fed diets supplemented with 0, 5, 10, 20, or 40 mg/kg of pyridoxine. The results showed that pyridoxine increased total follicle density, secondary follicle density, and the secondary-to-primary ratio. It also promoted the growth of hair stems and increased the growth length of hair follicles. Pyridoxine affected the gene expression of components of the PI3K/Akt, Wnt, and Notch signalling pathways, which are crucial for hair growth. However, it had no effect on the gene expression of BMP2, BMP4, or TGF-β1, components of the BMP signalling pathway. The study concluded that pyridoxine could potentially be used to promote hair growth and delay hair follicle degeneration.