Hair Follicle Development of Rex Rabbits Is Regulated Seasonally by Wnt10b/β-Catenin, TGFβ-BMP, IGF1, and EGF Signaling Pathways

December 2023 in “ Animals ”

Gongyan Liu, Ce Liu, Yin Zhang, Haitao Sun, Liping Yang, Liya Bai, Shuxia Gao

TLDR Winter provides the best fur quality for Rex rabbits due to seasonal changes in specific signaling pathways.

The study on Rex rabbits reveals that hair follicle development and fur quality are significantly influenced by seasonal changes, with winter being the optimal season. Winter skinning results in superior fur quality, higher skin weight, area, thickness, and hair follicle density compared to summer (p < 0.05). This is associated with increased expression of Wnt10b, CTNNB1, GSK3β, IGF-I, IGF-IR, and EGF genes, and decreased expression of DDK1, TGFβ-1, BMP2, and BMP4 genes. These findings highlight the role of the Wnt10b/β-catenin, TGFβ-BMP, IGF1, and EGF signaling pathways in regulating hair follicle development seasonally.

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