A Role for the TGF-β/BMP Co-Receptor Endoglin in the Molecular Oscillator That Regulates the Hair Follicle Cycle

September 2018 in “ Journal of Molecular Cell Biology ”

María I. Calvo-Sánchez, Sandra Fernández-Martos, Elisa Carrasco, Gema Moreno‐Bueno, Carmelo Bernabéu, Miguel Quintanilla, Jesús Espada

Endoglin Tgf-β Bmp hair follicle cycle hair follicle stem cell niches β-catenin Smad4 Wnt/β-catenin Bmp/Smad signals TGF-beta BMP hair cycle stem cell niches beta-catenin Wnt signaling Smad signaling

TLDR Endoglin is crucial for proper hair growth cycles and stem cell activation in mice.

The document from September 18, 2018, details a study on the role of Endoglin (Eng), a Tgf-β/Bmp co-receptor, in hair follicle cycling. The researchers used Eng haploinsufficient mice and found that Eng is essential for maintaining the correct hair follicle cycling pattern and stimulating hair follicle stem cell niches. They observed cyclic expression of Eng correlating with the hair cycle, with Eng haploinsufficient mice showing delayed entry into the hair cycle phases. The study also discovered that β-catenin binds to the Eng promoter in a Bmp signaling-dependent manner, and that β-catenin and Smad4 synergistically activate Eng promoter transcription. These findings suggest that Eng-dependent feedback between Wnt/β-catenin and Bmp/Smad signals may act as a molecular switch for the hair follicle growth/rest cycle. The altered hair follicle cycling was observed in 97% of analyzed animals (n=50).

View this study on academic.oup.com →

Discuss this study in the Community →

Research cited in this study

10 / 10 results

research Mouse Hair Cycle Expression Dynamics Modeled as Coupled Mesenchymal and Epithelial Oscillators

12 citations, November 2014 in “PLOS Computational Biology”

The study concluded that hair growth in mice is regulated by a stable interaction between skin cell types, and disrupting this can cause hair loss.

research Emerging Interactions Between Skin Stem Cells and Their Niches

426 citations, August 2014 in “Nature Medicine”

Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.

research Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation

321 citations, January 2012 in “Cell stem cell”

TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.

research Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells

176 citations, April 2011 in “Science”

Hair stem cell regeneration is controlled by signals that can explain different hair growth patterns and baldness.

research Biology and Genetics of Hair

89 citations, September 2010 in “Annual Review of Genomics and Human Genetics”

The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations, February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research Analyses of Regenerative Wave Patterns in Adult Hair Follicle Populations Reveal Macro-Environmental Regulation of Stem Cell Activity

64 citations, January 2009 in “The International journal of developmental biology”

Hair follicle stem cells are controlled by their surrounding environment.

research Complex Hair Cycle Domain Patterns and Regenerative Hair Waves in Living Rodents

127 citations, December 2007 in “Journal of Investigative Dermatology”

Mice hair growth patterns get more complex with age and can change with events like pregnancy or injury.

research Scratching the Surface of Skin Development

788 citations, February 2007 in “Nature”

The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.

research Growth of the Hair

521 citations, January 1954 in “Physiological Reviews”

Hair growth is cyclic and influenced mainly by local factors.

Similar Research

5 / 44 results

research A Role for the TGF-β/BMP Co-Receptor Endoglin in the Molecular Oscillator That Regulates the Hair Follicle Cycle

December 2017 in “bioRxiv (Cold Spring Harbor Laboratory)”

Endoglin is important for proper hair growth cycles and stem cell activation in hair follicles.

research Potential Natural Products Regulation of Molecular Signaling Pathway in Dermal Papilla Stem Cells

July 2023 in “Molecules”

Certain natural products may help stimulate hair growth by affecting stem cell activity in the scalp.

Establishment and Characterization of Matched Immortalized Human Frontal and Occipital Scalp Dermal Papilla Cell Lines from Androgenetic Alopecia

research Establishment and Characterization of Matched Immortalized Human Frontal and Occipital Scalp Dermal Papilla Cell Lines from Androgenetic Alopecia

December 2023 in “Scientific Reports”

Scientists created cell lines from balding patients and found that cells from the front of the scalp are more affected by hormones that cause hair loss than those from the back.

research Platelet Lysate Promotes Hair Growth: In Vitro and In Vivo Mechanism and Randomized, Controlled Trial

2 citations, March 2023 in “Biomedicine & pharmacotherapy”

Platelet lysate effectively promotes hair growth and improves hair thickness in people with androgenetic alopecia.

research Hair Follicle Development of Rex Rabbits Is Regulated Seasonally by Wnt10b/β-Catenin, TGFβ-BMP, IGF1, and EGF Signaling Pathways

1 citations, December 2023 in “Animals”

Winter provides the best fur quality for Rex rabbits due to seasonal changes in specific signaling pathways.